Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Oncology
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D Scott Cunningham MD, PhD
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1 Minimising critical organ irradiation in limited stage Hodgkin lymphoma: A dosimetric study of the benefit of involved node radiotherapy Full Text Annals of Oncology, October 8, 2012 Original Publication Date: October 7, 2011 Clinical Article
2 Clinical relevance of flow cytometric immunophenotyping of the cerebrospinal fluid in patients with diffuse large B-cell lymphoma Full Text Annals of Oncology, October 8, 2012 Original Publication Date: October 7, 2011
3 Multicenter, Phase II Study of Axitinib, a Selective Second-Generation Inhibitor of Vascular Endothelial Growth Factor Receptors 1, 2, 3, in Patients with Metastatic Melanoma Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 10, 2011 Clinical Article
4 A Phase I Dose Esclation Study of Tivantinib in Adult Pts w Metastatic Solid Tumors Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 10, 2011 Clinical Article
5 Phase I/II and Pharmacodynamic Study of Dovitinib (TKI258)-an Inhibitor of Fibroblast Growth Factor Receptors and VEGF Receptors-in Patients with Advanced Melanoma Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 10, 2011 Clinical Article
6 Repeated and Aggressive Pulmonary Resections for Leiomyosarcoma Metastases Extends Survival Full Text Annals of Thoracic Surgery, October 8, 2012 Original Publication Date: October 10, 2011
7 HIV envelope-mediated, CCR5/α4β7-dependent killing of CD4-negative γδ T cells which are lost during progression to AIDS Full Text Blood, October 8, 2012 Original Publication Date: October 10, 2011
8 Pam50 breast cancer subtyping by RT-QPCR and concordance with standard clinical molecular markers Full Text BMC Genomics, October 8, 2012
9 Breast vibro-acoustography: initial results show promise Full Text Breast Cancer Research, October 8, 2012
10 Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes Full Text Breast Cancer Research, October 8, 2012
11 Monocytes and the 38kDa-antigen of mycobacterium tuberculosis modulate natural killer cell activity and their cytolysis directed against ovarian cancer cell lines Full Text BMC Cancer, October 8, 2012
12 Falls in nursing home residents receiving pharmacotherapy for anemia Full Text Clinical Interventions in Aging, October 8, 2012
13 Phase I and pharmacokinetic study of pazopanib and lapatinib combination therapy in patients with advanced solid tumors Full Text Investigational New Drugs, October 8, 2012 Clinical Article
14 Body mass index, abdominal fatness and pancreatic cancer risk: A systematic review and non-linear doseresponse meta-analysis of prospective studies Full Text Annals of Oncology, October 7, 2012 Original Publication Date: October 6, 2011 Clinical Article
15 Adverse events risk associated with bevacizumab addition to breast cancer chemotherapy: a meta-analysis Full Text Annals of Oncology, October 7, 2012 Original Publication Date: October 7, 2011 Evidence Based Medicine Clinical Article
16 Carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in partially platinum-sensitive ovarian cancer patients: results from a subset analysis of the CALYPSO phase III trial Full Text Annals of Oncology, October 7, 2012 Original Publication Date: October 7, 2011 Clinical Article
17 The Effect of a Multidisciplinary Thoracic Malignancy Conference on the Treatment of Patients With Esophageal Cancer Full Text Annals of Thoracic Surgery, October 7, 2012 Original Publication Date: October 7, 2011
18 Pulmonary Resection for Metastatic Adrenocortical Carcinoma: The National Cancer Institute Experience Full Text Annals of Thoracic Surgery, October 7, 2012 Original Publication Date: October 7, 2011
19 The "Rib-Like" Technique for Surgical Treatment of Sternal Tumors: Lessons Learned From 101 Consecutive Cases Full Text Annals of Thoracic Surgery, October 7, 2012 Original Publication Date: October 7, 2011
20 Circulating tumor cells in immunohistochemical subtypes of metastatic breast cancer: lack of prediction in HER2-positive disease treated with targeted therapy Full Text Annals of Oncology, October 7, 2012 Original Publication Date: October 7, 2011
As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.
Read the article summaryAs reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.
Read the article summaryAs reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.
Read the article summaryIndexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more
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