Oncology News Articles

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The latest Cancer and Oncology news articles published daily by MDLinx physician editors who comb through the top peer-reviewed clinical journals for the medical articles that will make a difference to you and your practice. Organized by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants can stay current on latest oncology topics, symptoms, treatments, risk factors in Cancer and Hematology.

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1 Minimising critical organ irradiation in limited stage Hodgkin lymphoma: A dosimetric study of the benefit of involved node radiotherapy Full Text Annals of Oncology, October 8, 2012 Original Publication Date: October 7, 2011    Clinical Article

2 Clinical relevance of flow cytometric immunophenotyping of the cerebrospinal fluid in patients with diffuse large B-cell lymphoma Full Text Annals of Oncology, October 8, 2012 Original Publication Date: October 7, 2011

3 Multicenter, Phase II Study of Axitinib, a Selective Second-Generation Inhibitor of Vascular Endothelial Growth Factor Receptors 1, 2, 3, in Patients with Metastatic Melanoma Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 10, 2011    Clinical Article

4 A Phase I Dose Esclation Study of Tivantinib in Adult Pts w Metastatic Solid Tumors Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 10, 2011    Clinical Article

5 Phase I/II and Pharmacodynamic Study of Dovitinib (TKI258)-an Inhibitor of Fibroblast Growth Factor Receptors and VEGF Receptors-in Patients with Advanced Melanoma Full Text Clinical Cancer Research, October 8, 2012 Original Publication Date: October 10, 2011    Clinical Article

6 Repeated and Aggressive Pulmonary Resections for Leiomyosarcoma Metastases Extends Survival Full Text Annals of Thoracic Surgery, October 8, 2012 Original Publication Date: October 10, 2011

7 HIV envelope-mediated, CCR5/α4β7-dependent killing of CD4-negative γδ T cells which are lost during progression to AIDS Full Text Blood, October 8, 2012 Original Publication Date: October 10, 2011

8 Pam50 breast cancer subtyping by RT-QPCR and concordance with standard clinical molecular markers Full Text BMC Genomics, October 8, 2012

9 Breast vibro-acoustography: initial results show promise Full Text Breast Cancer Research, October 8, 2012

10 Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes Full Text Breast Cancer Research, October 8, 2012

11 Monocytes and the 38kDa-antigen of mycobacterium tuberculosis modulate natural killer cell activity and their cytolysis directed against ovarian cancer cell lines Full Text BMC Cancer, October 8, 2012

12 Falls in nursing home residents receiving pharmacotherapy for anemia Full Text Clinical Interventions in Aging, October 8, 2012

13 Phase I and pharmacokinetic study of pazopanib and lapatinib combination therapy in patients with advanced solid tumors Full Text Investigational New Drugs, October 8, 2012    Clinical Article

14 Body mass index, abdominal fatness and pancreatic cancer risk: A systematic review and non-linear doseresponse meta-analysis of prospective studies Full Text Annals of Oncology, October 7, 2012 Original Publication Date: October 6, 2011    Clinical Article

15 Adverse events risk associated with bevacizumab addition to breast cancer chemotherapy: a meta-analysis Full Text Annals of Oncology, October 7, 2012 Original Publication Date: October 7, 2011    Evidence Based Medicine    Clinical Article

16 Carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in partially platinum-sensitive ovarian cancer patients: results from a subset analysis of the CALYPSO phase III trial Full Text Annals of Oncology, October 7, 2012 Original Publication Date: October 7, 2011    Clinical Article

17 The Effect of a Multidisciplinary Thoracic Malignancy Conference on the Treatment of Patients With Esophageal Cancer Full Text Annals of Thoracic Surgery, October 7, 2012 Original Publication Date: October 7, 2011

18 Pulmonary Resection for Metastatic Adrenocortical Carcinoma: The National Cancer Institute Experience Full Text Annals of Thoracic Surgery, October 7, 2012 Original Publication Date: October 7, 2011

19 The "Rib-Like" Technique for Surgical Treatment of Sternal Tumors: Lessons Learned From 101 Consecutive Cases Full Text Annals of Thoracic Surgery, October 7, 2012 Original Publication Date: October 7, 2011

20 Circulating tumor cells in immunohistochemical subtypes of metastatic breast cancer: lack of prediction in HER2-positive disease treated with targeted therapy Full Text Annals of Oncology, October 7, 2012 Original Publication Date: October 7, 2011

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Clinical Pearls in Oncology

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Highlights in Oncology

Immunophenotype of small intestinal adenocarcinoma predicts survival

As reported in the European Journal of Obstetrics and Gynecology & Reproductive Biology, levels of the adipokine, apelin, are decreased in women with PCOS (n=45) compared to healthy controls. Apelin levels are positively correlated with BMI, insulin levels, triglycerides levels, free testosterone levels, the Ferriman-Gallwey score, and the HOMA index. Apelin levels are negatively correlated with HDL levels.

Loss of PTEN expression portends poor prognosis in IPMNs of the pancreas

As reported in Clinical Cancer Research, loss of PTEN in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas (n=36) is associated with invasiveness and poor survival.

CTC count predicts survival in mBC

As reported in The Lancet Oncology, circulating tumor cell (CTC) quantification in patients (20 studies; n = 1944) with metastatic breast cancer (mBC) predicts progression-free survival (PFS) and overall survival (OS), especially when coupled with clinicopathologic data. A CTC count ≥ 5/7.5 mL at baseline is associated with decreased PFS (HR = 1.92) and OS (HR = 2.78). An elevated CTC count 3-5 weeks and 6-8 weeks after treatment commences is also associated with decreased PFS (HR = 1.85 and 2.20) and OS (HR = 2.26 and 2.91).


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