Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Oncology
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1 Brain and Neck Tumors Among Physicians Performing Interventional Procedures The American Journal of Cardiology, May 20, 2013 Clinical Article
2 Ipilimumab in melanoma with limited brain metastases treated with stereotactic radiosurgery Melanoma Research, May 20, 2013 Clinical Article
3 Mobile phone use and risk of brain neoplasms and other cancers: prospective study International Journal of Epidemiology, May 20, 2013 Clinical Article
4 Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study The Lancet Oncology, May 20, 2013
5 Enhancing drug delivery for boron neutron capture therapy of brain tumors with focused ultrasound Neuro-Oncology, May 20, 2013 Clinical Article
6 Patterns of exposure to infectious diseases and social contacts in early life and risk of brain tumours in children and adolescents: an International Case-Control Study (CEFALO) British Journal of Cancer, May 20, 2013
7 Brain metastases from papillary thyroid carcinomas Virchows Archiv, May 20, 2013 Clinical Article
8 Premetastatic soil and prevention of breast cancer brain metastasis Neuro-Oncology, May 20, 2013 Clinical Article
9 Pilot study of vincristine, oral irinotecan, and temozolomide (VOIT regimen) combined with bevacizumab in pediatric patients with recurrent solid tumors or brain tumors Pediatric Blood & Cancer, May 20, 2013 Clinical Article
10 Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics Neuro-Oncology, May 20, 2013 Clinical Article
11 Response Classification Based on a Minimal Model of Glioblastoma Growth Is Prognostic for Clinical Outcomes and Distinguishes Progression from Pseudoprogression Cancer Research, May 20, 2013 Clinical Article
12 Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity Oncogene, May 20, 2013 Clinical Article
13 The molecular and cell biology of pediatric low-grade gliomas Oncogene, May 3, 2013 Review Article Clinical Article
14 Vemurafenib and radiation therapy in melanoma brain metastases Journal of Neuro-Oncology, May 3, 2013 Clinical Article
15 Prevalence, associations, and predictors of apathy in adult survivors of infantile (<5 years of age) posterior fossa brain tumors Neuro-Oncology, May 3, 2013 Review Article Clinical Article
16 Hypofractionated Stereotactic Radiotherapy with the Hypoxic Sensitizer AK-2123 (Sanazole) for Reirradiation of Brain Metastases: A Preliminary Feasibility Report Anticancer Research, May 3, 2013 Clinical Article
17 MicroRNAs involved in chemo- and radioresistance of high-grade gliomas Tumor Biology, May 3, 2013 Clinical Article
18 Pharmacokinetics and efficacy of pemetrexed in patients with brain or leptomeningeal metastases Journal of Neuro-Oncology, May 3, 2013 Clinical Article
19 Co-evolution of breast-to-brain metastasis and neural progenitor cells Clinical and Experimental Metastasis, May 3, 2013 Clinical Article
20 Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study The Lancet Oncology, May 3, 2013
21 Extent of peritumoral brain edema correlates with prognosis, tumoral growth pattern, HIF1a expression and angiogenic activity in patients with single brain metastases Clinical and Experimental Metastasis, May 3, 2013 Clinical Article
22 Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202) Journal of Clinical Oncology, April 16, 2013 Clinical Article
23 CNS metastases of breast cancer show discordant immunohistochemical phenotype compared to primary Journal of Cancer Research & Clinical Oncology, April 16, 2013 Clinical Article
24 Phase I Study of GRN1005 in Recurrent Malignant Glioma Clinical Cancer Research, April 16, 2013 Clinical Article
25 The Role of Radiosurgery to the Tumor Bed After Resection of Brain Metastases Neurosurgery, April 16, 2013 Clinical Article
26 Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition Clinical Cancer Research, April 16, 2013 Clinical Article
27 The effect of tumor subtype on the time from primary diagnosis to development of brain metastases and survival in patients with breast cancer Journal of Neuro-Oncology, April 16, 2013 Clinical Article
28 Snail depletes the tumorigenic potential of glioblastoma Oncogene, April 16, 2013 Clinical Article
29 The microtubule binding drug EM011 inhibits the growth of paediatric low grade gliomas Cancer Letters, April 16, 2013 Clinical Article
30 A systematic review of trastuzumab and lapatinib in the treatment of women with brain metastases from HER2-positive breast cancer Cancer Treatment Reviews, March 30, 2013 Review Article Clinical Article
31 Involved field radiation therapy after surgical resection of solitary brain metastases--mature results Neuro-Oncology, March 30, 2013 Clinical Article
32 Metastatic Melanoma to the Brain: Surgery and Radiation Is Still the Standard of Care Current Treatment Options in Oncology, March 30, 2013 Clinical Article
33 Prognostic significance of the aggregative perivascular growth pattern of tumor cells in primary central nervous system diffuse large B-cell lymphoma Neuro-Oncology, March 30, 2013
34 The effectiveness of erlotinib against brain metastases in non-small cell lung cancer patients American Journal of Clinical Oncology, March 30, 2013 Clinical Article
35 Risk of subsequent cancer following a primary CNS tumor Journal of Neuro-Oncology, March 30, 2013 Clinical Article
36 Incidence and risk of central nervous system metastases as site of first recurrence in patients with HER2-positive breast cancer treated with adjuvant trastuzumab Annals of Oncology, March 13, 2013 Clinical Article
37 CNS metastases in non-small-cell lung cancer: Current role of EGFR-TKI therapy and future perspectives Lung Cancer, March 13, 2013 Clinical Article
38 SIOP CNS GCT 96: final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease Neuro-Oncology, March 13, 2013 Clinical Article
39 Primary CNS germ cell tumors: current epidemiology and update on treatment Medical Oncology, March 13, 2013 Review Article
As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.
Read the article summaryAs reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.
Read the article summaryAs reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.
Read the article summary1 Radiotherapy or tamoxifen after conserving surgery for breast cancers of excellent prognosis: British Association of Surgical Oncology (BASO) II trial European Journal of Cancer, April 2, 2013
2 R-CVP versus R-CHOP versus R-FM for the initial treatment of patients with advanced-stage follicular lymphoma: Results of the FOLL05 Trial conducted by the Fondazione Italiana Linfomi Journal of Clinical Oncology, April 1, 2013
3 Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013 Mayo Clinic Proceedings, April 2, 2013 Clinical Guideline
4 Ipilimumab alone or in combination with radiotherapy in metastatic castration-resistant prostate cancer: results from an open-label, multicenter phase I/II study Annals of Oncology, April 3, 2013
5 Phase 2 study of dose-intense temozolomide in recurrent glioblastoma Neuro-Oncology, April 9, 2013
6 Estrogen plus progestin and breast cancer incidence and mortality in the Women's Health Initiative Observational Study Journal of the National Cancer Institute, April 4, 2013
7 Randomised phase 3 open-label trial of first-line treatment with gemcitabine in association with docetaxel or paclitaxel in women with metastatic breast cancer: a comparison of different schedules and treatments BMC Cancer, April 3, 2013 Free full text
8 Exemestane Versus Anastrozole in Postmenopausal Women With Early Breast Cancer: NCIC CTG MA.27--A Randomized Controlled Phase III Trial Journal of Clinical Oncology, February 11, 2013
9 Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial The Lancet Oncology, March 12, 2013
10 Effect of low-dose tamoxifen after surgical excision of ductal intraepithelial neoplasia: results of a large retrospective monoinstitutional cohort study Annals of Oncology, April 1, 2013
11 High pretreatment serum lactate dehydrogenase level correlates with disease relapse and predicts an inferior outcome in locally advanced nasopharyngeal carcinoma European Journal of Cancer, April 5, 2013
12 Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2×2 factorial trial The Lancet Oncology, April 12, 2013
13 Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202) Journal of Clinical Oncology, April 15, 2013
14 Analysis in early stage triple-negative breast cancer treated with mastectomy without adjuvant radiotherapy: Patterns of failure and prognostic factors Cancer, April 11, 2013
15 Comparative effectiveness of three platinum-doublet chemotherapy regimens in elderly patients with advanced non-small cell lung cancer Cancer, April 10, 2013
16 Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial The Lancet Oncology, February 15, 2013
17 Neoadjuvant chemotherapy with paclitaxel and everolimus in breast cancer patients with non-responsive tumours to epirubicin/cyclophosphamide (EC)±bevacizumab: Results of the randomised GeparQuinto study (GBG 44) European Journal of Cancer, April 5, 2013
18 Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT-0116/SWOG9008 clinical trial Annals of Oncology, April 4, 2013
19 Antitumour activity of abiraterone acetate against metastatic castration-resistant prostate cancer progressing after docetaxel and enzalutamide (MDV3100) Annals of Oncology, April 16, 2013
20 R-CHOP therapy alone in limited stage diffuse large B-cell lymphoma British Journal of Haematology, March 1, 2013
Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more
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