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Oncology - BMT/SCT News & Articles
Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.
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Articles
Latest (2) Full Text Articles (175) Focus on Pancreas561 High alloreactivity of low dose prophylactic donor lymphocyte infusions in acute leukemia patients transplanted with alemtuzumab Biology of Blood and Marrow Transplantation, August 8, 2012
562 Treatment of young patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia using increased dose of imatinib and deintensified chemotherapy before allogeneic stem cell transplantation British Journal of Haematology, August 7, 2012
563 Prevention of Nausea and Vomiting Associated with Stem Cell Transplantation: Results of a Prospective, Randomized Trial of Aprepitant used with Highly Emetogenic Preparative Regimens Biology of Blood and Marrow Transplantation, August 6, 2012
564 Effects of conditioning regimens and T-cell depletion in hematopoietic cell transplantation for primary immune deficiency Biology of Blood and Marrow Transplantation, August 6, 2012
565 Late Effects in Hematopoietic Cell Transplant Recipients with Acquired Severe Aplastic Anemia Biology of Blood and Marrow Transplantation, August 6, 2012
566 Effects of intensified conditioning on Epstein-Barr virus and cytomegalovirus infections in allogeneic hematopoietic stem cell transplantation for hematological malignancies Journal of Hematology & Oncology, August 6, 2012
567 Upfront Autologuos Stem-Cell Transplantation in Peripheral T-Cell Lymphoma Journal of Clinical Oncology, August 2, 2012
568 NT-pro-BNP: not the prognostic all-rounder in elderly patients undergoing allogeneic stem cell transplantation Annals of Hematology, August 2, 2012
569 The use of adjusted ideal body weight for overweight patients undergoing HPC mobilisation for autologous transplantation Annals of Hematology, August 2, 2012
570 Impact of Donor Characteristics and Human Leukocyte Antigen Matching on Survival of Chinese Patients with Hematological Malignancies Undergoing Unrelated Hematopoietic Stem Cell Transplantation Biology of Blood and Marrow Transplantation, August 1, 2012
571 Quantification of minimal residual disease levels by flow cytometry at time of transplant predicts outcome after myeloablative allogeneic transplantation in ALL Bone Marrow Transplantation, August 1, 2012
572 Outcome of treatment after first relapse in younger adults with acute myeloid leukemia initially treated by the ALFA-9802 trial Leukemia Research, July 27, 2012
573 Allogeneic hematopoietic stem cell transplantation in adolescent and adult patients with high risk T-cell acute lymphoblastic leukemia Biology of Blood and Marrow Transplantation, July 26, 2012
574 Norovirus infection in pediatric hematopoietic stem cell transplant recipients: incidence, risk factors and outcome Biology of Blood and Marrow Transplantation, July 25, 2012
575 Reduced intensity allogeneic hematopoietic stem cell transplantation for MDS using tacrolimus/sirolimus-based GVHD prophylaxis Leukemia Research, July 25, 2012 Clinical Article
576 Effect of HLA-matching recipients to donor non-inherited maternal antigens on outcomes after mismatched umbilical cord blood transplantation for hematologic malignancy Biology of Blood and Marrow Transplantation, July 25, 2012
577 Allogeneic stem cell transplantation for myeloproliferative neoplasm in blast phase Leukemia Research, July 25, 2012
578 Role of autologous hematopoietic stem-cell transplantation according the NPM1/FLT3-ITD molecular status for cytogenetically normal AML patients American Journal of Hematology, July 20, 2012
579 Large granular lymphocyte expansion following allogeneic hematopoietic stem cell transplantation is associated with a cytomegalovirus reactivation and shows an indolent outcome Biology of Blood and Marrow Transplantation, July 19, 2012
580 Addition of plerixafor to mobilization regimens in autologous peripheral blood stem cell transplants does not affect the correlation of pre-harvest hematopoietic precursor cell (HPC) enumeration with first harvest CD34+stem cell yield Biology of Blood and Marrow Transplantation, July 19, 2012
Clinical Pearls in Oncology
- The ZORO study demonstrated that the addition of goserelin to neoadjuvant chemotherapy for early breast cancer in premenopausal women resulted in no change in post-chemotherapy rates of amenorrhea
- A little over 50% of tumors in women with ER-positive, node-negative breast cancers will have a RS <18, and current data suggests that these women are UNLIKELY to receive a benefit from adjuvant chemotherapy
- In patients with completely resected ER-positive DCIS when the surgical specimen also has LCIS, consider breast MRI screening in addition to mammography due to the lower sensitivity of mammograms for lobular disease
Highlights in Oncology
VEGFR-1 is a prognostic marker for HCC
As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.
Read the article summaryHCC risk increased in patients with AIDS
As reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.
Read the article summaryRAB25 is a prognostic marker for ovarian cancer
As reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.
Read the article summaryMost Popular Oncology Articles
Last month's top read Top Articles of 20121 Allogeneic hematopoietic cell transplantation for consolidation of VGPR or CR for newly diagnosed multiple myeloma Bone Marrow Transplantation, April 3, 2013
2 Disease status and stem cell source impact on the results of reduced intensity conditioning transplant for Hodgkin lymphoma: a retrospective study from the French Society of Bone Marrow Graft Transplantation and Cellular Therapy Haematologica, April 4, 2013 Free full text Review Article
3 Donor lymphocyte infusion for relapsed hematological malignancies after allogeneic hematopoietic cell transplantation: prognostic relevance of the initial CD3+ T cell dose Biology of Blood and Marrow Transplantation, April 1, 2013
4 Clinical Guide to ABO Incompatible Allogeneic Stem Cell Transplantation Biology of Blood and Marrow Transplantation, April 12, 2013
5 Somatic hypermutation analysis in follicular lymphoma provides evidence suggesting bidirectional cell migration between lymph node and bone marrow during disease progression and relapse Haematologica, April 15, 2013 Free full text Review Article
6 Graft-Versus-Host Disease and Graft-Versus-Tumor Effects After Allogeneic Hematopoietic Cell Transplantation Journal of Clinical Oncology, March 19, 2013
7 Comparison of outcomes after two standards-of-care RIC regimens and two different graft sources (FB2A2-PBSC vs dUCB-TCF) for allogeneic stem cells transplantation (allo-SCT) in adults with haematological diseases: a single centre analysis Biology of Blood and Marrow Transplantation, April 2, 2013
8 Increase of suicide and accidental death after hematopoietic stem cell transplantation Cancer, March 25, 2013
9 Allogeneic Hematopoietic Cell Transplantation for Fanconi Anemia in Patients With Pretransplantation Cytogenetic Abnormalities, Myelodysplastic Syndrome, or Acute Leukemia Journal of Clinical Oncology, April 5, 2013
10 Autologous retransplantation for patients with recurrent multiple myeloma Cancer, April 15, 2013
11 Application of five prognostic survival scores to primary myelofibrosis in 62 Brazilian patients Medical Oncology, April 12, 2013
12 Three-Dimensional Virtual Bone Bank System Workflow for Structural Bone Allograft Selection: A Technical Report Sarcoma, April 19, 2013
13 Busulfan Dose Intensity and Outcomes in Reduced Intensity Allogeneic Peripheral Blood Stem Cell Transplantation for MDS/AML Biology of Blood and Marrow Transplantation, April 8, 2013
14 Impact of pre-transplant marrow blasts on survival of allogeneic stem cell transplantation in adult acute myeloid leukemia International Journal of Hematology, April 3, 2013
15 Mitigating effects of hUCB-MSCs on the hematopoietic syndrome resulting from total body irradiation Experimental Hematology, April 15, 2013
16 Characteristics of chronic GVHD after cord blood transplantation Bone Marrow Transplantation, April 18, 2013
17 Autologous Umbilical Cord Blood (UCB) Infusion Followed by Oral Docosahexanoic Acid (DHA) and Vitamin D (VitD) Supplementation for C-Peptide Preservation in Children with Type 1 Diabetes (T1D) Biology of Blood and Marrow Transplantation, April 24, 2013
18 The hematopoietic cell transplantation-specific comorbidity index (HCT-CI) is an outcome predictor for partially matched related donor transplantation American Journal of Hematology, April 1, 2013
19 Determining the optimal time for bortezomib-based induction chemotherapy followed by autologous hematopoietic stem cell transplant in the treatment of multiple myeloma Chinese Journal of Cancer Research, April 16, 2013 Free full text
20 A case-control study of bronchiolitis obliterans syndrome following allogeneic hematopoietic stem cell transplantation Transplant International, April 9, 2013
Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more
Other Topics in Oncology
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