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Peds Heme/Oncology News & Articles

Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.

On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (7) Full Text Articles (216) Focus on Bone
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

61 Childhood leukemia and lymphoma: time trends and factors affecting survival in five Southern and Eastern European Cancer Registries Cancer Causes and Control, May 7, 2013    Review Article

62 A comparative analysis of paediatric dose-finding trials of molecularly targeted agent with adults trials European Journal of Cancer, May 6, 2013    Clinical Article

63 Intensity-modulated radiotherapy (IMRT) in pediatric low-grade glioma Cancer, May 6, 2013    Clinical Article

64 Symptomatic Epidural Compression in Infants With Neuroblastoma: A Single-Center Experience With 5 Cases Journal of Pediatric Hematology/Oncology, May 6, 2013

65 Physical Performance of Nontransplanted Childhood ALL Survivors is Comparable to Healthy Controls Journal of Pediatric Hematology/Oncology, May 6, 2013    Clinical Article

66 Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study The Lancet Oncology, May 3, 2013

67 Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study The Lancet Oncology, May 3, 2013    Clinical Article

68 Multiple pilomatricomas with somatic CTNNB1 mutations in children with constitutive mismatch repair deficiency Genes, Chromosomes and Cancer, May 3, 2013    Clinical Article

69 MicroRNAs and Recent Insights into Pediatric Ovarian Cancers Frontiers in Oncology, May 3, 2013    Clinical Article

70 LGR5 is Expressed by Ewing Sarcoma and Potentiates Wnt/β-Catenin Signaling Frontiers in Oncology, May 3, 2013    Clinical Article

71 Advanced Targeted, Cell and Gene-Therapy Approaches for Pediatric Hematological Malignancies: Results and Future Perspectives Frontiers in Oncology, May 3, 2013    Clinical Article

72 Diffuse Leptomeningeal Neuroepithelial Tumor: 9 Pediatric Cases With Chromosome 1p/19q Deletion Status and IDH1 (R132H) Immunohistochemistry American Journal of Surgical Pathology , May 3, 2013    Clinical Article

73 Biology of Childhood Acute Lymphoblastic Leukemia Journal of Pediatric Hematology/Oncology, May 3, 2013    Review Article

74 Bereaved Parents and Siblings Offer Advice to Health Care Providers and Researchers Journal of Pediatric Hematology/Oncology, May 3, 2013    Clinical Article

75 Survival of pediatric patients after relapsed osteosarcoma: The St. Jude Childrens Research Hospital experience Cancer, May 2, 2013

76 NUP98-NSD1 gene fusion and its related gene expression signature are strongly associated with a poor prognosis in pediatric acute myeloid leukemia Genes, Chromosomes and Cancer, May 2, 2013    Clinical Article

77 Sickle Cell-related Bone Marrow Complications: The Utility of Diffusion-weighted Magnetic Resonance Imaging Journal of Pediatric Hematology/Oncology, May 2, 2013    Clinical Article

78 Outcome and toxicity using helical tomotherapy for craniospinal irradiation in pediatric medulloblastoma Clinical and Translational Oncology, May 2, 2013    Clinical Article

79 Conventional and Advanced MRI Features of Pediatric Intracranial Tumors: Supratentorial Tumors American Journal of Roentgenology, May 2, 2013    Review Article

80 The molecular and cell biology of pediatric low-grade gliomas Oncogene, May 1, 2013    Review Article    Clinical Article

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Clinical Pearls in Oncology

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.

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HCC risk increased in patients with AIDS

As reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.

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RAB25 is a prognostic marker for ovarian cancer

As reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.

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Most Popular Oncology Articles

Last month's top read Top Articles of 2012

1 Fertility treatment and childhood cancer risk: A systematic meta-analysis Fertility and Sterility, April 8, 2013    Evidence Based Medicine    Review Article

2 Childhood leukaemia close to high-voltage power lines – the Geocap study, 2002–2007 British Journal of Cancer, April 17, 2013    Review Article

3 Low Serum Lipocalin Levels in Patients With Iron Deficiency Anemia Journal of Pediatric Hematology/Oncology, April 1, 2013

4 What is the relevance of Ikaros gene deletions as prognostic marker in pediatric Philadelphia negative B-cell precursor acute lymphoblastic leukemia? Haematologica, April 15, 2013    Free full text

5 Exposure to pesticides and the risk of childhood brain tumors Cancer Causes and Control, April 10, 2013

6 Tumor origin and growth pattern at diagnosis and surgical hypothalamic damage predict obesity in pediatric craniopharyngioma Journal of Neuro-Oncology, April 16, 2013

7 Evaluation of memory impairment in aging adult survivors of childhood acute lymphoblastic leukemia treated with cranial radiotherapy Journal of the National Cancer Institute, April 18, 2013

8 Long term follow-up of survivors of childhood cancer: summary of updated SIGN guidance British Medical Journal, April 9, 2013    Clinical Guideline

9 Outcome of infants and young children with newly diagnosed ependymoma treated on the Head Start III prospective clinical trial Journal of Neuro-Oncology, March 25, 2013

10 A 10-year follow up of reproductive function in women treated for childhood cancer Reproductive BioMedicine Online, April 26, 2013

11 Allogeneic Hematopoietic Cell Transplantation in First Remission Abrogates Poor Outcomes Associated with High-Risk Pediatric Acute Myeloid Leukemia Biology of Blood and Marrow Transplantation, April 11, 2013

12 Thoracoscopic resection of computed tomography-localized lung nodules in children Journal of Pediatric Surgery, April 23, 2013    Review Article
Exclusive Author Commentary

13 A comparative analysis of paediatric dose-finding trials of molecularly targeted agent with adults trials European Journal of Cancer, April 2, 2013

14 Bone marrow evaluation for pediatric patients International Journal of Laboratory Hematology, April 26, 2013    Review Article

15 FDG PET/CT in children and adolescents with lymphoma Pediatric Radiology, March 25, 2013    Review Article

16 Salvage allogeneic hematopoietic SCT for primary graft failure in children Bone Marrow Transplantation, March 27, 2013    Review Article

17 Moderate Aplastic Anemia in Children: Preliminary Outcomes for Treatment Versus Observation From a Single-Institutional Experience Journal of Pediatric Hematology/Oncology, March 4, 2013

18 Cardiac Magnetic Resonance Imaging in the Evaluation of the Late Effects of Anthracyclines Among Long-Term Survivors of Childhood Cancer JACC - Journal of the American College of Cardiology, April 5, 2013

19 Transfusion-associated hyperkalemic cardiac arrest in pediatric patients receiving massive transfusion Transfusion, April 19, 2013

20 FoxG1 Interacts with Bmi1 to Regulate Self-Renewal and Tumorigenicity of Medulloblastoma Stem Cells Stem Cells, April 22, 2013

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncologymore

Other Topics in Oncology

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