Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.
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1 Notch signaling mediates melanoma-endothelial cell communication and melanoma cell migration Pigment Cell & Melanoma Research, June 19, 2013 Review Article
2 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Imaging in the Management of Merkel Cell Carcinoma: A Single-Institution Retrospective Study Dermatologic Surgery, June 19, 2013 Review Article
3 Suggested excisional margins for cutaneous malignant lesions based on mohs micrographic surgery JAMA Facial Plastic Surgery, June 19, 2013 Review Article
4 Cytoplasmic vacuoles: Clue in the fine-needle aspiration diagnosis of melanoma Diagnostic Cytopathology, June 19, 2013 Clinical Article
5 Patients undergoing lymphadenectomy for stage III melanomas of known or unknown primary site do not differ in outcome International Journal of Cancer, June 19, 2013 Clinical Article
6 Geography of non-melanoma skin cancer and ecological associations with environmental risk factors in England British Journal of Cancer, June 19, 2013 Clinical Article
7 Survivin promotion of melanoma metastasis requires upregulation of {alpha}5 integrin Carcinogenesis, June 19, 2013 Review Article
8 Peroxiredoxin-2 represses melanoma metastasis by increasing E-cadherin/β-catenin complexes in adherens junctions Cancer Research, June 18, 2013 Clinical Article
9 Systematic review and meta-analysis of liver resection for metastatic melanoma British Journal of Surgery, June 18, 2013 Evidence Based Medicine Review Article
10 Primary cutaneous CD4+ small to medium-size pleomorphic T-cell lymphoma in a 12-year-old girl Pediatric Dermatology, June 18, 2013
11 Telomere length and risk of melanoma, squamous cell carcinoma, and basal cell carcinoma Cancer Epidemiology, June 17, 2013
12 Primary cutaneous marginal zone lymphomas with plasmacytic differentiation show frequent IgG4 expression Modern Pathology, June 17, 2013 Clinical Article
13 Is complete lymph node dissection after a positive sentinel lymph node biopsy for cutaneous melanoma always necessary? A meta-analysis European Journal of Surgical Oncology, June 17, 2013 Evidence Based Medicine Review Article
14 Desmoplastic melanoma: A 12-year experience with sentinel lymph node biopsy European Journal of Surgical Oncology, June 17, 2013 Review Article
15 Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy Journal of Clinical Oncology, June 13, 2013 Clinical Article
16 Developing a common language for tumor response to immunotherapy: immune-related response criteria using unidimentional measurements Clinical Cancer Research, June 13, 2013 Clinical Article
17 Ras, raf, and map kinase in melanoma Advances in Anatomic Pathology , June 12, 2013 Review Article
18 PET/CT images of bilateral diffuse intraglomerular metastasis of malignant melanoma Clinical Nuclear Medicine , June 12, 2013
19 Exposure-response relationships of the efficacy and safety of ipilimumab in patients with advanced melanoma Clinical Cancer Research, June 10, 2013 Clinical Article
20 A cutaneous lymphoma international prognostic index (CLIPi) for mycosis fungoides and Sezary syndrome European Journal of Cancer, June 10, 2013 Clinical Article
As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.
Read the article summaryAs reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.
Read the article summaryAs reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.
Read the article summary1 Four-year survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials Annals of Oncology, May 14, 2013
2 A randomized phase II trial of multi-epitope vaccination with melanoma peptides for cytotoxic T-cells and helper T-cells for patients with metastatic melanoma (E1602) Clinical Cancer Research, May 13, 2013
3 Anorectal and genital mucosal melanoma is associated with cutaneous melanoma in patients and in families British Journal of Dermatology, May 16, 2013
4 Predicting Disease Progression After Regional Therapy for In-Transit Melanoma Disease Progression After Regional Therapy JAMA Surgery, April 9, 2013 Review Article
5 Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial The Lancet Oncology, May 16, 2013
6 Phase II study of the Src kinase inhibitor saracatinib (AZD0530) in metastatic melanoma Investigational New Drugs, May 7, 2013
7 Isolated cerebral susceptibility artefacts in patients with malignant melanoma: metastasis or not European Radiology, May 16, 2013 Review Article
8 Is Head and Neck Melanoma Different from Trunk and Extremity Melanomas with Respect to Sentinel Lymph Node Status and Clinical Outcome? Annals of Surgical Oncology, May 13, 2013
9 Management of external ear melanoma: the same or something different? The American Journal of Surgery, May 21, 2013
10 Improvement of the sentinel lymph node detection rate of cervical sentinel lymph node biopsy using real-time fluorescence navigation with indocyanine green in head and neck skin cancer The Journal of Dermatology, May 3, 2013
11 Combined ipsilateral neck and axillary lymphadenectomy for metastatic skin cancers: A case series and surgical tips Journal of Plastic, Reconstructive & Aesthetic Surgery, May 17, 2013
12 P21-activated kinase 1 (pak1) as a therapeutic target in braf wild-type melanoma Journal of the National Cancer Institute, April 1, 2013
13 Ipilimumab in melanoma with limited brain metastases treated with stereotactic radiosurgery Melanoma Research, May 10, 2013
14 Margins of excision and prognostic factors for cutaneous eyelid melanomas Journal of Plastic, Reconstructive & Aesthetic Surgery, May 28, 2013 Review Article
15 Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth Cancer Prevention Research, May 6, 2013
16 The new ajcc guidelines in practice: utility of the mitf immunohistochemical stain in the evaluation of single-cell metastasis in melanoma sentinel lymph nodes American Journal of Surgical Pathology , May 24, 2013 Clinical Guideline
17 Analysis of surrogate gene expression markers in peripheral blood of melanoma patients to predict treatment outcome of adjuvant pegylated interferon alpha 2b Cancer Immunology, Immunotherapy, May 2, 2013
18 The impact of comorbidity and stage on prognosis of Danish melanoma patients, 1987-2009: a registry-based cohort study British Journal of Cancer, May 20, 2013
19 Impaired PIASy-Tip60 signaling weakens activation of p53 in melanoma Melanoma Research, May 1, 2013
20 Merkel Cell Carcinoma: Diagnosis, Management, and Outcomes Plastic and Reconstructive Surgery, May 7, 2013 Review Article
Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more
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