Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.
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101 Novel Targets in the Treatment of Advanced Melanoma: New First-Line Treatment Options Annals of Pharmacotherapy, April 10, 2013 Clinical Article
102 Phase II Trial of MEK Inhibitor Selumetinib (AZD6244, ARRY-142886) in Patients with BRAFV600E/K-Mutated Melanoma Clinical Cancer Research, April 10, 2013 Clinical Article
103 Effects of BRAF inhibitors on Human Melanoma Tissue Before Treatment, Early During Treatment and on Progression Pigment Cell & Melanoma Research, April 10, 2013 Clinical Article
104 Management of advanced non-melanoma skin cancers using helical tomotherapy Journal of the European Academy of Dermatology and Venereology, April 10, 2013 Clinical Article
105 Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control Clinical Cancer Research, April 9, 2013 Clinical Article
106 Amiodarone and the risk of cancer Cancer, April 9, 2013 Clinical Article
107 Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cells Do Not Require Expression of the Viral Small T Antigen Journal of Investigative Dermatology, April 9, 2013 Clinical Article
108 Predicting Disease Progression After Regional Therapy for In-Transit Melanoma Disease Progression After Regional Therapy JAMA Surgery, April 9, 2013 Review Article
109 U.S. Food and Drug Administration Approval: Vismodegib for Recurrent, Locally Advanced or Metastatic Basal Cell Carcinoma Clinical Cancer Research, April 8, 2013 Clinical Article
110 p38{alpha} Signaling Contributes to Solar UV-Induced Skin Tumorigenesis Cancer Research, April 8, 2013 Clinical Article
111 Clinicopathologic Features of Primary Merkel Cell Carcinoma: A Detailed Descriptive Analysis of a Large Contemporary Cohort Dermatologic Surgery, April 8, 2013 Clinical Article
112 Unusual Morphologic Presentations of Blastic Plasmacytoid Dendritic Cell Neoplasm: Report of Two Cases Misdiagnosed as Melanoma and Leprosy International Journal of Surgical Pathology, April 8, 2013
113 Expression of proliferation markers and cell cycle regulators in T cell lymphoproliferative skin disorders Journal of Dermatological Science, April 8, 2013 Clinical Article
114 Prospective study of genital human papillomaviruses and non-melanoma skin cancer International Journal of Cancer, April 5, 2013
115 Dermoid cysts of the Eustachian tube: A transnasal excision International Journal of Pediatric Otorhinolaryngology , April 5, 2013
116 Hydroa vacciniforme-like cutaneous T-cell lymphoma: Clinicopathologic and immunohistochemical study of 12 cases Journal of the American Academy of Dermatology, April 4, 2013
117 CD34-Positive Superficial Myxofibrosarcoma: A Potential Diagnostic Pitfall Journal of Cutaneous Pathology, April 4, 2013 Review Article Clinical Article
118 Disease Progression and Patient Survival Are Significantly Influenced by BRAF Protein Expression in Primary Melanoma British Journal of Dermatology, April 3, 2013 Clinical Article
119 Anvirzel in combination with cisplatin in breast, colon, lung, prostate, melanoma and pancreatic cancer cell lines Full Text BMC Pharmacology & Toxicology, April 3, 2013 Clinical Article
120 Dermoscopic patterns of Melanoma Metastases: inter-observer consistency and accuracy for metastases recognition British Journal of Dermatology, April 2, 2013 Clinical Article
As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.
Read the article summaryAs reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.
Read the article summaryAs reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.
Read the article summary1 Completion lymph node dissection after a positive sentinel node: no longer a must Current Opinion in Oncology, March 4, 2013 Review Article
2 Rare BRAF mutations in melanoma patients: implications for molecular testing in clinical practice British Journal of Cancer, April 12, 2013 Review Article
3 P21-activated kinase 1 (pak1) as a therapeutic target in braf wild-type melanoma Journal of the National Cancer Institute, April 1, 2013
4 Mohs Versus Surgical Excision in Nonmelanoma Skin Cancers: Does Location Matter? Annals of Plastic Surgery, April 11, 2013 Review Article
5 Clinicopathologic Features of Primary Merkel Cell Carcinoma: A Detailed Descriptive Analysis of a Large Contemporary Cohort Dermatologic Surgery, April 8, 2013
6 Long-term survival and immunological parameters in metastatic melanoma patients who responded to ipilimumab 10mg/kg within an expanded access programme Cancer Immunology, Immunotherapy, April 23, 2013
7 Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma Journal of Clinical Oncology, January 10, 2013
8 Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control Clinical Cancer Research, April 9, 2013
9 Predicting Disease Progression After Regional Therapy for In-Transit Melanoma Disease Progression After Regional Therapy JAMA Surgery, April 9, 2013 Review Article
10 MERTK receptor tyrosine kinase is a therapeutic target in melanoma The Journal of Clinical Investigation, April 25, 2013 Free full text
11 Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control Clinical Cancer Research, March 4, 2013
12 Advanced basal cell carcinoma of the skin: targeting the hedgehog pathway Current Opinion in Oncology, April 24, 2013 Review Article
13 Clinical activity and safety of combination therapy with temsirolimus and bevacizumab for advanced melanoma: A Phase II trial (CTEP 7190/ Mel47) Clinical Cancer Research, April 29, 2013
14 Occupational exposure to arsenic and risk of non-melanoma skin cancer in a multinational European study International Journal of Cancer, April 25, 2013
15 Establishment of a novel experimental model of human angiosarcoma and a VEGF-targeting therapeutic experiment Journal of Dermatological Science, April 1, 2013
16 Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy Clinical and Experimental Dermatology, March 28, 2013
17 Lymph/angiogenesis gene variants and melanoma progression Cancer Epidemiology, Biomarkers & Prevention, April 17, 2013
18 Superficial and deep lymph node dissection for stage III cutaneous melanoma: clinical outcome and prognostic factors World Journal of Surgical Oncology, February 12, 2013
19 Effects of BRAF inhibitors on Human Melanoma Tissue Before Treatment, Early During Treatment and on Progression Pigment Cell & Melanoma Research, April 10, 2013
20 Amiodarone and the risk of cancer Cancer, April 9, 2013
Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more
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