Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Oncology
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D Scott Cunningham MD, PhD
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Markers of obesity and inflammation in postmenopausal breast cancer
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21 Increasing rates of low-risk human papillomavirus infections in patients with oral cavity squamous cell carcinoma: Association with clinical outcomes Journal of Clinical Virology, May 15, 2013 Clinical Article
22 Four-year survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials Annals of Oncology, May 14, 2013 Clinical Article
23
Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with Lentigo Maligna Melanoma in a Mediterranean population
British Journal of Dermatology, May 14, 2013
Clinical Article
Exclusive Author Commentary
24 Late Recurrence in Melanoma: Clinical Implications of Lost Dormancy Journal of the American College of Surgeons, May 14, 2013 Clinical Article
25 A randomized phase II trial of multi-epitope vaccination with melanoma peptides for cytotoxic T-cells and helper T-cells for patients with metastatic melanoma (E1602) Clinical Cancer Research, May 13, 2013 Clinical Article
26 Odontogenic ameloblast-associated protein (ODAM) inhibits growth and migration of human melanoma cells and elicits PTEN elevation and inactivation of PI3K/AKT signaling Full Text BMC Cancer, May 13, 2013 Review Article
27 The Impact of Escitalopram on IL-2-Induced Neuroendocrine, Immune, and Behavioral Changes in Patients with Malignant Melanoma: Preliminary Findings Neuropsychopharmacology, May 13, 2013
28 Pathologic Features of Pediatric Head and Neck Melanoma Pediatric Dermatology, May 13, 2013 Review Article
29 Is Head and Neck Melanoma Different from Trunk and Extremity Melanomas with Respect to Sentinel Lymph Node Status and Clinical Outcome? Annals of Surgical Oncology, May 13, 2013 Clinical Article
30 Ipilimumab in melanoma with limited brain metastases treated with stereotactic radiosurgery Melanoma Research, May 10, 2013 Clinical Article
31 Conjunctival Melanomas harbor BRAF and NRAS Mutations and Copy Number Changes Similar to Cutaneous and Mucosal Melanomas Clinical Cancer Research, May 10, 2013 Clinical Article
32 Risk of subsequent cutaneous malignancy in patients with prior keratinocyte carcinoma: A systematic review and meta-analysis European Journal of Cancer, May 10, 2013 Review Article
33 Socioeconomic status as a predictor of melanoma survival in a series of 1083 cases from Brazil: just a marker of health services accessibility Melanoma Research, May 10, 2013 Review Article
34 Randomized selection design trial evaluating CD8+-enriched versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy for patients with melanoma Journal of Clinical Oncology, May 9, 2013
35 Association between tuberculosis infections and non-pulmonary malignancies: a nationwide population-based study British Journal of Cancer, May 9, 2013
36 Phase I study of tremelimumab (CP-675 206) plus PF-3512676 (CPG 7909) in patients with melanoma or advanced solid tumours British Journal of Cancer, May 9, 2013 Clinical Article
37 Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: a review and update Human Pathology, May 9, 2013 Review Article
38 Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2-dependent mechanisms Cancer Research, May 9, 2013 Review Article
39 Treatment of Nonfatal Conditions at the End of Life Nonmelanoma Skin Cancer JAMA Internal Medicine, May 8, 2013 Evidence Based Medicine Clinical Article
40 Analysis of Latvian familial melanoma patients shows novel variants in the noncoding regions of CDKN2A and that the CDK4 mutation R24H is a founder mutation Melanoma Research, May 8, 2013 Clinical Article
As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.
Read the article summaryAs reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.
Read the article summaryAs reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.
Read the article summary1 Completion lymph node dissection after a positive sentinel node: no longer a must Current Opinion in Oncology, March 4, 2013 Review Article
2 Rare BRAF mutations in melanoma patients: implications for molecular testing in clinical practice British Journal of Cancer, April 12, 2013 Review Article
3 P21-activated kinase 1 (pak1) as a therapeutic target in braf wild-type melanoma Journal of the National Cancer Institute, April 1, 2013
4 Mohs Versus Surgical Excision in Nonmelanoma Skin Cancers: Does Location Matter? Annals of Plastic Surgery, April 11, 2013 Review Article
5 Clinicopathologic Features of Primary Merkel Cell Carcinoma: A Detailed Descriptive Analysis of a Large Contemporary Cohort Dermatologic Surgery, April 8, 2013
6 Long-term survival and immunological parameters in metastatic melanoma patients who responded to ipilimumab 10mg/kg within an expanded access programme Cancer Immunology, Immunotherapy, April 23, 2013
7 Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma Journal of Clinical Oncology, January 10, 2013
8 Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control Clinical Cancer Research, April 9, 2013
9 Predicting Disease Progression After Regional Therapy for In-Transit Melanoma Disease Progression After Regional Therapy JAMA Surgery, April 9, 2013 Review Article
10 MERTK receptor tyrosine kinase is a therapeutic target in melanoma The Journal of Clinical Investigation, April 25, 2013 Free full text
11 Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control Clinical Cancer Research, March 4, 2013
12 Advanced basal cell carcinoma of the skin: targeting the hedgehog pathway Current Opinion in Oncology, April 24, 2013 Review Article
13 Clinical activity and safety of combination therapy with temsirolimus and bevacizumab for advanced melanoma: A Phase II trial (CTEP 7190/ Mel47) Clinical Cancer Research, April 29, 2013
14 Occupational exposure to arsenic and risk of non-melanoma skin cancer in a multinational European study International Journal of Cancer, April 25, 2013
15 Establishment of a novel experimental model of human angiosarcoma and a VEGF-targeting therapeutic experiment Journal of Dermatological Science, April 1, 2013
16 Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy Clinical and Experimental Dermatology, March 28, 2013
17 Lymph/angiogenesis gene variants and melanoma progression Cancer Epidemiology, Biomarkers & Prevention, April 17, 2013
18 Superficial and deep lymph node dissection for stage III cutaneous melanoma: clinical outcome and prognostic factors World Journal of Surgical Oncology, February 12, 2013
19 Effects of BRAF inhibitors on Human Melanoma Tissue Before Treatment, Early During Treatment and on Progression Pigment Cell & Melanoma Research, April 10, 2013
20 Amiodarone and the risk of cancer Cancer, April 9, 2013
Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more
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