Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.
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321 The Proteasome Inhibitor Bortezomib Stimulates Osteoblastic Differentiation of Human Osteoblast Precursors via Upregulation of Vitamin D Receptor Signalling European Journal of Haematology, January 15, 2013 Clinical Article
322 The characterization and potential impact of melanoma cases with unknown thickness in the United States Surveillance, Epidemiology, and End Results Program, 1989-2008 Cancer Epidemiology, January 14, 2013
323 BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma Clinical Cancer Research, January 14, 2013 Clinical Article
324 A knockdown of Maml1 that results in melanoma cell senescence promotes an innate and adaptive immune response Cancer Immunology, Immunotherapy, January 14, 2013 Review Article
325 Phase I trial of bortezomib and dacarbazine in melanoma and soft tissue sarcoma Investigational New Drugs, January 14, 2013 Clinical Article
326 Cutaneous malignancies in xeroderma pigmentosum: earlier management improves survival Indian Journal of Otolaryngology and Head & Neck Surgery, January 11, 2013 Review Article
327 High lipid content of irradiated human melanoma cells does not affect cytokine-matured dendritic cell function Cancer Immunology, Immunotherapy, January 11, 2013 Clinical Article
328 FDG PET scans as evaluation of clinical response to dendritic cell vaccination in patients with malignant melanoma Cancer Immunology, Immunotherapy, January 11, 2013 Clinical Article
329 Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma Journal of Clinical Oncology, January 10, 2013
330 Merkel cell polyomavirus infection in both components of a combined Merkel cell carcinoma and basal cell carcinoma with ductal differentiation; each component had a similar but different novel Merkel cell polyomavirus large T antigen truncating mutation Human Pathology, January 10, 2013 Clinical Article
331 Use of Arsenic-Induced Palmoplantar Hyperkeratosis and Skin Cancers to Predict Risk of Subsequent Internal Malignancy American Journal of Epidemiology, January 10, 2013 Clinical Article
332 Altered expression of the miRNA processing endoribonuclease Dicer has prognostic significance in human cancers Expert Review of Anticancer Therapy, January 10, 2013 Clinical Article
333 Incidence of Residual Nonmelanoma Skin Cancer in Excisions After Shave Biopsy Dermatologic Surgery, January 10, 2013 Clinical Article
334 Reflectance confocal microscopy in the diagnosis of partially and completely amelanotic melanoma: report on seven cases Journal of the European Academy of Dermatology and Venereology, January 10, 2013 Review Article
335 The impact of dermatological toxicities of anti-cancer therapy on the dermatological quality of life of cancer patients Journal of the European Academy of Dermatology and Venereology, January 10, 2013 Clinical Guideline Clinical Article
336 A focus on pd-l1 in human melanoma Clinical Cancer Research, January 8, 2013 Clinical Guideline Clinical Article
337 S100A9 Is a Novel Ligand of EMMPRIN That Promotes Melanoma Metastasis Cancer Research, January 8, 2013 Clinical Article
338 Clinical and Sociodemographic Characteristics Associated With Thick Melanomas A Population-Based, Case-Case Study in France Characteristics Associated With Thick Melanomas JAMA Dermatology, January 7, 2013
339 HIV Infection Status, Immunodeficiency, and the Incidence of Non-Melanoma Skin Cancer Journal of the National Cancer Institute, January 7, 2013 Clinical Article
340 Genetic alterations in RAS regulated pathway in Acral Lentiginous Melanoma Experimental Dermatology, January 4, 2013 Review Article
As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.
Read the article summaryAs reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.
Read the article summaryAs reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.
Read the article summary1 Four-year survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials Annals of Oncology, May 14, 2013
2 A randomized phase II trial of multi-epitope vaccination with melanoma peptides for cytotoxic T-cells and helper T-cells for patients with metastatic melanoma (E1602) Clinical Cancer Research, May 13, 2013
3 Anorectal and genital mucosal melanoma is associated with cutaneous melanoma in patients and in families British Journal of Dermatology, May 16, 2013
4 Predicting Disease Progression After Regional Therapy for In-Transit Melanoma Disease Progression After Regional Therapy JAMA Surgery, April 9, 2013 Review Article
5 Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial The Lancet Oncology, May 16, 2013
6 Phase II study of the Src kinase inhibitor saracatinib (AZD0530) in metastatic melanoma Investigational New Drugs, May 7, 2013
7 Isolated cerebral susceptibility artefacts in patients with malignant melanoma: metastasis or not European Radiology, May 16, 2013 Review Article
8 Is Head and Neck Melanoma Different from Trunk and Extremity Melanomas with Respect to Sentinel Lymph Node Status and Clinical Outcome? Annals of Surgical Oncology, May 13, 2013
9 Management of external ear melanoma: the same or something different? The American Journal of Surgery, May 21, 2013
10 Improvement of the sentinel lymph node detection rate of cervical sentinel lymph node biopsy using real-time fluorescence navigation with indocyanine green in head and neck skin cancer The Journal of Dermatology, May 3, 2013
11 Combined ipsilateral neck and axillary lymphadenectomy for metastatic skin cancers: A case series and surgical tips Journal of Plastic, Reconstructive & Aesthetic Surgery, May 17, 2013
12 P21-activated kinase 1 (pak1) as a therapeutic target in braf wild-type melanoma Journal of the National Cancer Institute, April 1, 2013
13 Ipilimumab in melanoma with limited brain metastases treated with stereotactic radiosurgery Melanoma Research, May 10, 2013
14 Margins of excision and prognostic factors for cutaneous eyelid melanomas Journal of Plastic, Reconstructive & Aesthetic Surgery, May 28, 2013 Review Article
15 Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth Cancer Prevention Research, May 6, 2013
16 The new ajcc guidelines in practice: utility of the mitf immunohistochemical stain in the evaluation of single-cell metastasis in melanoma sentinel lymph nodes American Journal of Surgical Pathology , May 24, 2013 Clinical Guideline
17 Analysis of surrogate gene expression markers in peripheral blood of melanoma patients to predict treatment outcome of adjuvant pegylated interferon alpha 2b Cancer Immunology, Immunotherapy, May 2, 2013
18 The impact of comorbidity and stage on prognosis of Danish melanoma patients, 1987-2009: a registry-based cohort study British Journal of Cancer, May 20, 2013
19 Impaired PIASy-Tip60 signaling weakens activation of p53 in melanoma Melanoma Research, May 1, 2013
20 Merkel Cell Carcinoma: Diagnosis, Management, and Outcomes Plastic and Reconstructive Surgery, May 7, 2013 Review Article
Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more
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