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Dermatologic Oncology News & Articles

Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.

On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (2) Full Text Articles (147) Focus on Liver
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

301 Denileukin diftitox for the treatment of CD25 low-expression mycosis fungoides and Sezary syndrome Leukemia and Lymphoma, December 18, 2012

302 Oncogenic B-RAFV600E Signaling Induces the T-Box3 Transcriptional Repressor to Repress E-Cadherin and Enhance Melanoma Cell Invasion Journal of Investigative Dermatology, December 18, 2012

303 Patterns of Response in Patients with Pretreated Metastatic Melanoma who Received Ipilimumab 3 mg/kg in a European Expanded Access Program: Five Illustrative Case Reports Cancer Investigation, December 18, 2012

304 Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma Journal of the National Cancer Institute, December 18, 2012

305 The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma Oncogene, December 18, 2012

306 Clinical use of p-proteasome in discriminating metastatic melanoma patients: Comparative study with LDH, MIA and S100B protein International Journal of Cancer, December 14, 2012

307 BRAF inhibitor activity in V600R metastatic melanoma European Journal of Cancer, December 14, 2012

308 Atrophic dermatofibrosarcoma protuberans: report of a case demonstrated by detecting COL1A1- PDGFB rearrangement Diagnostic Pathology, December 13, 2012

309 Assessment of mitotic rate reporting in melanoma The American Journal of Surgery, December 12, 2012

310 Positivity for HLA DR1 is associated with basal cell carcinoma in renal transplant patients in southern Brazil International Journal of Dermatology, December 11, 2012

311 Desmoplastic Malignant Melanoma: A Study of Ten Cases and Status of BRAF Mutation Dermatology, December 11, 2012

312 Specific Lymphocyte Subsets Predict Response to Adoptive Cell Therapy Using Expanded Autologous Tumor-Infiltrating Lymphocytes in Metastatic Melanoma Patients Clinical Cancer Research, December 10, 2012

313 Trends in Basal Cell Carcinoma Incidence Rates: A 37-Year Dutch Observational Study Journal of Investigative Dermatology, December 10, 2012

314 Inhibition of mTOR suppresses UVB-induced keratinocyte proliferation and survival Cancer Prevention Research, December 7, 2012

315 A Phase III Skin Cancer Chemoprevention Study of DFMO: Long-term Follow-up of Skin Cancer Events and Toxicity Cancer Prevention Research, December 7, 2012

316 Clinical and Safety Profile of High-Dose Interleukin-2 Treatment in Elderly Patients with Metastatic Melanoma and Renal Cell Carcinoma Oncology, December 7, 2012

317 Preservation of the deep muscular fascia and locoregional control in melanoma Surgery, December 7, 2012

318 The TWEAK Receptor Fn14 Is a Therapeutic Target in Melanoma: Immunotoxins Targeting Fn14 Receptor for Malignant Melanoma Treatment Journal of Investigative Dermatology, December 6, 2012

319 Dermal Equivalents in Oncology: Benefit of One-Stage Procedure Dermatologic Surgery, December 6, 2012

320 Obesity and risk of malignant melanoma: A meta-analysis of cohort and case?control studies European Journal of Cancer, December 5, 2012

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Clinical Pearls in Oncology

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.

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HCC risk increased in patients with AIDS

As reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.

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RAB25 is a prognostic marker for ovarian cancer

As reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.

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Most Popular Oncology Articles

Last month's top read Top Articles of 2012

1 Completion lymph node dissection after a positive sentinel node: no longer a must Current Opinion in Oncology, March 4, 2013    Review Article

2 Rare BRAF mutations in melanoma patients: implications for molecular testing in clinical practice British Journal of Cancer, April 12, 2013    Review Article

3 P21-activated kinase 1 (pak1) as a therapeutic target in braf wild-type melanoma Journal of the National Cancer Institute, April 1, 2013

4 Mohs Versus Surgical Excision in Nonmelanoma Skin Cancers: Does Location Matter? Annals of Plastic Surgery, April 11, 2013    Review Article

5 Clinicopathologic Features of Primary Merkel Cell Carcinoma: A Detailed Descriptive Analysis of a Large Contemporary Cohort Dermatologic Surgery, April 8, 2013

6 Long-term survival and immunological parameters in metastatic melanoma patients who responded to ipilimumab 10mg/kg within an expanded access programme Cancer Immunology, Immunotherapy, April 23, 2013

7 Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma Journal of Clinical Oncology, January 10, 2013

8 Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control Clinical Cancer Research, April 9, 2013

9 Predicting Disease Progression After Regional Therapy for In-Transit Melanoma Disease Progression After Regional Therapy JAMA Surgery, April 9, 2013    Review Article

10 MERTK receptor tyrosine kinase is a therapeutic target in melanoma The Journal of Clinical Investigation, April 25, 2013    Free full text

11 Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control Clinical Cancer Research, March 4, 2013

12 Advanced basal cell carcinoma of the skin: targeting the hedgehog pathway Current Opinion in Oncology, April 24, 2013    Review Article

13 Clinical activity and safety of combination therapy with temsirolimus and bevacizumab for advanced melanoma: A Phase II trial (CTEP 7190/ Mel47) Clinical Cancer Research, April 29, 2013

14 Occupational exposure to arsenic and risk of non-melanoma skin cancer in a multinational European study International Journal of Cancer, April 25, 2013

15 Establishment of a novel experimental model of human angiosarcoma and a VEGF-targeting therapeutic experiment Journal of Dermatological Science, April 1, 2013

16 Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy Clinical and Experimental Dermatology, March 28, 2013

17 Lymph/angiogenesis gene variants and melanoma progression Cancer Epidemiology, Biomarkers & Prevention, April 17, 2013

18 Superficial and deep lymph node dissection for stage III cutaneous melanoma: clinical outcome and prognostic factors World Journal of Surgical Oncology, February 12, 2013

19 Effects of BRAF inhibitors on Human Melanoma Tissue Before Treatment, Early During Treatment and on Progression Pigment Cell & Melanoma Research, April 10, 2013

20 Amiodarone and the risk of cancer Cancer, April 9, 2013

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncologymore

Other Topics in Oncology

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