Dermatologic Oncology News & Articles

Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.

On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.

Your Unread Messages in Oncology

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D Scott Cunningham MD, PhD
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Articles

Latest (2) Full Text Articles (147) Focus on Lung

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

281 S100A9 Is a Novel Ligand of EMMPRIN That Promotes Melanoma Metastasis Cancer Research, January 8, 2013 Clinical Article

282 Clinical and Sociodemographic Characteristics Associated With Thick Melanomas A Population-Based, Case-Case Study in France Characteristics Associated With Thick Melanomas JAMA Dermatology, January 7, 2013

283 HIV Infection Status, Immunodeficiency, and the Incidence of Non-Melanoma Skin Cancer Journal of the National Cancer Institute, January 7, 2013 Clinical Article

284 Genetic alterations in RAS regulated pathway in Acral Lentiginous Melanoma Experimental Dermatology, January 4, 2013 Review Article

285 Tangential Shave Removal of Basal Cell Carcinoma Dermatologic Surgery, January 4, 2013 Clinical Article

286 Skin cancer in the elderly – epidemiological, clinical and surgical treatment analysis of 254 patients Advances in Dermatology and Allergology, January 3, 2013 Clinical Article

287 Squamous cell carcinoma as a long-term effect after skin vascular malformation radiotherapy Advances in Dermatology and Allergology, January 3, 2013

288 Increased Tumor Necrosis Factor (TNF)-alpha and Its Promoter Polymorphisms Correlate with Disease Progression and Higher Susceptibility towards Vitiligo PLOS ONE, January 3, 2013 Review Article
Exclusive Author Commentary

289 Achieving the Relocation Accuracy of Stereotactic Frame-based Cranial Radiotherapy in a Three-point Thermoplastic Shell Clinical Oncology, January 2, 2013
Exclusive Author Commentary

290 Deregulation of protein methylation in melanoma European Journal of Cancer, January 2, 2013 Review Article

291 The association between cancer and amyotrophic lateral sclerosis Cancer Causes and Control, December 27, 2012

292 PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells Molecular Carcinogenesis, December 21, 2012

293 Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma Journal of Clinical Oncology, December 20, 2012

294 Phase II study of the MEK1/MEK2 inhibitor trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor Journal of Clinical Oncology, December 20, 2012

295 Altered expression patterns of clock gene mRNAs and clock proteins in human skin tumors Tumor Biology, December 20, 2012

296 Cutaneous B-cell lymphomas: 2013 update on diagnosis, risk-stratification, and management American Journal of Hematology, December 20, 2012

297 DNA repair and replication proteins as prognostic markers in melanoma Histopathology, December 20, 2012

298 TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma Cells Cancer Research, December 19, 2012

299 Mutant B-RAF regulates a Rac-dependent cadherin switch in melanoma Oncogene, December 19, 2012

300 Systemic sclerosis (scleroderma) and cancer risk: systematic review and meta-analysis of observational studies Rheumatology, December 18, 2012 Evidence Based Medicine Clinical Article

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Clinical Pearls in Oncology

The ZORO study demonstrated that the addition of goserelin to neoadjuvant chemotherapy for early breast cancer in premenopausal women resulted in no change in post-chemotherapy rates of amenorrhea
A little over 50% of tumors in women with ER-positive, node-negative breast cancers will have a RS <18, and current data suggests that these women are UNLIKELY to receive a benefit from adjuvant chemotherapy
In patients with completely resected ER-positive DCIS when the surgical specimen also has LCIS, consider breast MRI screening in addition to mammography due to the lower sensitivity of mammograms for lobular disease

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.

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HCC risk increased in patients with AIDS

As reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.

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RAB25 is a prognostic marker for ovarian cancer

As reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.

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Most Popular Oncology Articles

Last month's top read Top Articles of 2012

1 Completion lymph node dissection after a positive sentinel node: no longer a must Current Opinion in Oncology, March 4, 2013 Review Article

2 Rare BRAF mutations in melanoma patients: implications for molecular testing in clinical practice British Journal of Cancer, April 12, 2013 Review Article

3 P21-activated kinase 1 (pak1) as a therapeutic target in braf wild-type melanoma Journal of the National Cancer Institute, April 1, 2013

4 Mohs Versus Surgical Excision in Nonmelanoma Skin Cancers: Does Location Matter? Annals of Plastic Surgery, April 11, 2013 Review Article

5 Clinicopathologic Features of Primary Merkel Cell Carcinoma: A Detailed Descriptive Analysis of a Large Contemporary Cohort Dermatologic Surgery, April 8, 2013

6 Long-term survival and immunological parameters in metastatic melanoma patients who responded to ipilimumab 10mg/kg within an expanded access programme Cancer Immunology, Immunotherapy, April 23, 2013

7 Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma Journal of Clinical Oncology, January 10, 2013

8 Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control Clinical Cancer Research, April 9, 2013

9 Predicting Disease Progression After Regional Therapy for In-Transit Melanoma Disease Progression After Regional Therapy JAMA Surgery, April 9, 2013 Review Article

10 MERTK receptor tyrosine kinase is a therapeutic target in melanoma The Journal of Clinical Investigation, April 25, 2013 Free full text

11 Efficacy and safety of retreatment with ipilimumab in patients with pretreated advanced melanoma who progressed after initially achieving disease control Clinical Cancer Research, March 4, 2013

12 Advanced basal cell carcinoma of the skin: targeting the hedgehog pathway Current Opinion in Oncology, April 24, 2013 Review Article

13 Clinical activity and safety of combination therapy with temsirolimus and bevacizumab for advanced melanoma: A Phase II trial (CTEP 7190/ Mel47) Clinical Cancer Research, April 29, 2013

14 Occupational exposure to arsenic and risk of non-melanoma skin cancer in a multinational European study International Journal of Cancer, April 25, 2013

15 Establishment of a novel experimental model of human angiosarcoma and a VEGF-targeting therapeutic experiment Journal of Dermatological Science, April 1, 2013

16 Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy Clinical and Experimental Dermatology, March 28, 2013

17 Lymph/angiogenesis gene variants and melanoma progression Cancer Epidemiology, Biomarkers & Prevention, April 17, 2013

18 Superficial and deep lymph node dissection for stage III cutaneous melanoma: clinical outcome and prognostic factors World Journal of Surgical Oncology, February 12, 2013

19 Effects of BRAF inhibitors on Human Melanoma Tissue Before Treatment, Early During Treatment and on Progression Pigment Cell & Melanoma Research, April 10, 2013

20 Amiodarone and the risk of cancer Cancer, April 9, 2013

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more

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Dermatologic Oncology News & Articles

Articles

Clinical Pearls in Oncology

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

HCC risk increased in patients with AIDS

RAB25 is a prognostic marker for ovarian cancer

Most Popular Oncology Articles

Other Topics in Oncology