Oncology - Soft Tissue/Sarcoma News & Articles

Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.

On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (1) Full Text Articles (114) Focus on Head & neck

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

101 Pulmonary Metastasectomy for Sarcoma of Gynaecologic Origin Heart, Lung, and Circulation, April 5, 2013 Clinical Article

102 Dedifferentiated Peripheral Chondrosarcoma: A Review of Radiologic Characteristics Sarcoma, April 4, 2013 Review Article Clinical Article

103 CD34-Positive Superficial Myxofibrosarcoma: A Potential Diagnostic Pitfall Journal of Cutaneous Pathology, April 4, 2013 Review Article Clinical Article

104 High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma Cancer Research, April 2, 2013 Clinical Article

105 Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway Cancer Research, April 2, 2013 Clinical Article

106 Targeted treatment for advanced soft tissue sarcoma: profile of pazopanib Full Text OncoTargets and Therapy, April 2, 2013 Review Article Clinical Article

107 Do Malignant Bone Tumors of the Foot Have a Different Biological Behavior than Sarcomas at Other Skeletal Sites Sarcoma, April 1, 2013 Clinical Article

108 Induction of Cell Cycle Arrest and Apoptosis in Human Osteosarcoma U-2 OS Cells by Solanum lyratum Extracts Nutrition and Cancer, March 29, 2013 Clinical Article

109 Radiation Therapy for Angiosarcoma: The 35-year University of Florida Experience American Journal of Clinical Oncology, March 29, 2013 Clinical Article

110 Dermoscopy of dermatofibrosarcoma protuberans: a study of 15 cases British Journal of Dermatology, March 28, 2013 Clinical Article

111 Advanced soft-tissue sarcoma in elderly patients: patterns of care and survival Annals of Oncology, March 27, 2013 Review Article

112 Outcome of patients with advanced solitary fibrous tumors: the Centre Leon Berard experience Full Text BMC Cancer, March 27, 2013 Clinical Article

113 Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of osteosarcoma cells by switching on suppressor microRNAs and inactivating of Notch-1 signaling Carcinogenesis, March 27, 2013 Clinical Article

114 Can HMGI-C be used as an aid with MDM2 and CDK4 to differentiate liposarcoma subtypes from their mimics Journal of Cancer Research & Clinical Oncology, March 27, 2013 Clinical Article

115 Outcome Prediction in Primary Resected Retroperitoneal Soft Tissue Sarcoma: Histology-Specific Overall Survival and Disease-Free Survival Nomograms Built on Major Sarcoma Center Data Sets [Sarcomas] Journal of Clinical Oncology, March 27, 2013 Clinical Article

116 A Pilot Study of Anti-CTLA4 Antibody Ipilimumab in Patients with Synovial Sarcoma Sarcoma, March 26, 2013 Clinical Article

117 Multiple primary malignancies in elderly patients with high-grade soft tissue sarcoma International Journal of Clinical Oncology, March 25, 2013 Clinical Article

118 Prognostic significance of p53 expression in malignant bone tumors: a meta-analysis Tumor Biology, March 21, 2013 Clinical Article

119 Results of a phase I dose escalation study of eltrombopag in patients with advanced soft tissue sarcoma receiving doxorubicin and ifosfamide Full Text BMC Cancer, March 20, 2013 Clinical Article

120 Multiple splice variants of EWSR1-ETS fusion transcripts co-existing in the Ewing sarcoma family of tumors Cellular Oncology, March 20, 2013 Clinical Article

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Clinical Pearls in Oncology

The ZORO study demonstrated that the addition of goserelin to neoadjuvant chemotherapy for early breast cancer in premenopausal women resulted in no change in post-chemotherapy rates of amenorrhea
A little over 50% of tumors in women with ER-positive, node-negative breast cancers will have a RS <18, and current data suggests that these women are UNLIKELY to receive a benefit from adjuvant chemotherapy
In patients with completely resected ER-positive DCIS when the surgical specimen also has LCIS, consider breast MRI screening in addition to mammography due to the lower sensitivity of mammograms for lobular disease

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.

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HCC risk increased in patients with AIDS

As reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.

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RAB25 is a prognostic marker for ovarian cancer

As reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.

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Most Popular Oncology Articles

Last month's top read Top Articles of 2012

1 Cediranib for Metastatic Alveolar Soft Part Sarcoma Journal of Clinical Oncology, May 6, 2013

2 Survival of pediatric patients after relapsed osteosarcoma: The St. Jude Childrens Research Hospital experience Cancer, May 2, 2013

3 Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis Journal of Clinical Oncology, May 17, 2013 Review Article

4 Transcutaneous electrical nerve stimulation for treatment of sarcoma cancer pain Pain Management, May 20, 2013

5 Activity endpoints reported in soft tissue sarcoma phase II trials: quality of reported endpoints and correlation with overall survival Critical Reviews in Oncology/Hematology, May 29, 2013 Evidence Based Medicine Review Article

6 Expression of FGFR3 and FGFR4 and clinical risk factors associated with progression-free survival in synovial sarcoma Human Pathology, May 16, 2013

7 Molecular Distinction of Chondrosarcoma From Chondroblastic Osteosarcoma Through IDH1/2 Mutations American Journal of Surgical Pathology , May 15, 2013

8 Vincristine, Irinotecan, and Temozolomide for Treatment of Relapsed Alveolar Rhabdomyosarcoma Journal of Pediatric Hematology/Oncology, April 29, 2013

9 Minnelide reduces tumor burden in preclinical models of osteosarcoma Cancer Letters, May 1, 2013

10 From the radiologic pathology archives: ewing sarcoma family of tumors: radiologic-pathologic correlation RadioGraphics, May 23, 2013

11 Regulation of Target Genes of PAX3-FOXO1 in Alveolar Rhabdomyosarcoma Anticancer Research, May 14, 2013

12 Sorafenib in patients with progressive epithelioid hemangioendothelioma Cancer, April 25, 2013

13 The strength of small: Improved targeting of Insulin-like Growth Factor-1 Receptor (IGF-1R) with F(ab')2-R1507 fragments in Ewing sarcomas European Journal of Cancer, May 14, 2013

14 Carcinosarcoma of the liver: report of a case Surgery Today, May 13, 2013 Review Article

15 Clinical report on transarterial neoadjuvant chemotherapy of malignant fibrous histiocytoma in soft tissue Clinical and Translational Oncology, May 2, 2013 Review Article

16 High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma Cancer Research, April 2, 2013

17 Antibody-dependent cell lysis by NK cells is preserved after sarcoma-induced inhibition of NK cell cytotoxicity Cancer Immunology, Immunotherapy, April 30, 2013

18 Targeting FoxM1 Effectively Retards p53-Null Lymphoma and Sarcoma Molecular Cancer Therapeutics, May 14, 2013

19 Galectin-1 (GAL-1) expression is a useful tool to differentiate between small cell osteosarcoma and Ewing sarcoma Virchows Archiv, May 22, 2013

20 ASS1 as a novel tumor suppressor gene in myxofibrosarcomas: aberrant loss via epigenetic dna methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance Clinical Cancer Research, May 24, 2013

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more

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Oncology - Soft Tissue/Sarcoma News & Articles

Articles

Clinical Pearls in Oncology

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

HCC risk increased in patients with AIDS

RAB25 is a prognostic marker for ovarian cancer

Most Popular Oncology Articles

Other Topics in Oncology