Oncology - Soft Tissue/Sarcoma News & Articles

Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.

On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (1) Full Text Articles (114) Focus on Head & neck

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

41 ASS1 as a novel tumor suppressor gene in myxofibrosarcomas: aberrant loss via epigenetic dna methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance Clinical Cancer Research, May 24, 2013 Clinical Article

42 From the radiologic pathology archives: ewing sarcoma family of tumors: radiologic-pathologic correlation RadioGraphics, May 23, 2013 Clinical Article

43 Galectin-1 (GAL-1) expression is a useful tool to differentiate between small cell osteosarcoma and Ewing sarcoma Virchows Archiv, May 22, 2013 Clinical Article

44 Transcutaneous electrical nerve stimulation for treatment of sarcoma cancer pain Pain Management, May 20, 2013 Clinical Article

45 Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis Journal of Clinical Oncology, May 17, 2013 Review Article

46 Expression of FGFR3 and FGFR4 and clinical risk factors associated with progression-free survival in synovial sarcoma Human Pathology, May 16, 2013 Clinical Article

47 TGF-β1 suppression of microRNA-450b-5p expression: a novel mechanism for blocking myogenic differentiation of rhabdomyosarcoma Oncogene, May 15, 2013 Clinical Article

48 Molecular Distinction of Chondrosarcoma From Chondroblastic Osteosarcoma Through IDH1/2 Mutations American Journal of Surgical Pathology , May 15, 2013 Clinical Article

49 The strength of small: Improved targeting of Insulin-like Growth Factor-1 Receptor (IGF-1R) with F(ab')2-R1507 fragments in Ewing sarcomas European Journal of Cancer, May 14, 2013 Clinical Article

50 Regulation of Target Genes of PAX3-FOXO1 in Alveolar Rhabdomyosarcoma Anticancer Research, May 14, 2013 Clinical Article

51 Targeting FoxM1 Effectively Retards p53-Null Lymphoma and Sarcoma Molecular Cancer Therapeutics, May 14, 2013 Clinical Article

52 Spinal anaesthesia for caesarean section in the presence of respiratory failure and spinal metastases from a soft tissue clear cell sarcoma International Journal of Obstetric Anesthesia , May 14, 2013

53 Carcinosarcoma of the liver: report of a case Surgery Today, May 13, 2013 Review Article

54 HMGA2-IGF2BP2 Regulates NRAS in Rhabdomyosarcoma Cancer Research, May 10, 2013 Review Article

55 Follicle-stimulating hormone receptor expression in soft tissue sarcomas Histopathology, May 10, 2013 Clinical Article

56 CD99 suppresses osteosarcoma cell migration through inhibition of ROCK2 activity Oncogene, May 8, 2013 Clinical Article

57 Cediranib for Metastatic Alveolar Soft Part Sarcoma Journal of Clinical Oncology, May 6, 2013 Clinical Article

58 Frequent PLAG1 gene rearrangements in skin and soft tissue myoepithelioma with ductal differentiation Genes, Chromosomes and Cancer, May 3, 2013 Clinical Article

59 LGR5 is Expressed by Ewing Sarcoma and Potentiates Wnt/β-Catenin Signaling Frontiers in Oncology, May 3, 2013 Clinical Article

60 Survival of pediatric patients after relapsed osteosarcoma: The St. Jude Childrens Research Hospital experience Cancer, May 2, 2013

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Clinical Pearls in Oncology

The ZORO study demonstrated that the addition of goserelin to neoadjuvant chemotherapy for early breast cancer in premenopausal women resulted in no change in post-chemotherapy rates of amenorrhea
A little over 50% of tumors in women with ER-positive, node-negative breast cancers will have a RS <18, and current data suggests that these women are UNLIKELY to receive a benefit from adjuvant chemotherapy
In patients with completely resected ER-positive DCIS when the surgical specimen also has LCIS, consider breast MRI screening in addition to mammography due to the lower sensitivity of mammograms for lobular disease

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.

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HCC risk increased in patients with AIDS

As reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.

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RAB25 is a prognostic marker for ovarian cancer

As reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.

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Most Popular Oncology Articles

Last month's top read Top Articles of 2012

1 Cediranib for Metastatic Alveolar Soft Part Sarcoma Journal of Clinical Oncology, May 6, 2013

2 Survival of pediatric patients after relapsed osteosarcoma: The St. Jude Childrens Research Hospital experience Cancer, May 2, 2013

3 Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis Journal of Clinical Oncology, May 17, 2013 Review Article

4 Transcutaneous electrical nerve stimulation for treatment of sarcoma cancer pain Pain Management, May 20, 2013

5 Activity endpoints reported in soft tissue sarcoma phase II trials: quality of reported endpoints and correlation with overall survival Critical Reviews in Oncology/Hematology, May 29, 2013 Evidence Based Medicine Review Article

6 Expression of FGFR3 and FGFR4 and clinical risk factors associated with progression-free survival in synovial sarcoma Human Pathology, May 16, 2013

7 Molecular Distinction of Chondrosarcoma From Chondroblastic Osteosarcoma Through IDH1/2 Mutations American Journal of Surgical Pathology , May 15, 2013

8 Vincristine, Irinotecan, and Temozolomide for Treatment of Relapsed Alveolar Rhabdomyosarcoma Journal of Pediatric Hematology/Oncology, April 29, 2013

9 Minnelide reduces tumor burden in preclinical models of osteosarcoma Cancer Letters, May 1, 2013

10 From the radiologic pathology archives: ewing sarcoma family of tumors: radiologic-pathologic correlation RadioGraphics, May 23, 2013

11 Regulation of Target Genes of PAX3-FOXO1 in Alveolar Rhabdomyosarcoma Anticancer Research, May 14, 2013

12 Sorafenib in patients with progressive epithelioid hemangioendothelioma Cancer, April 25, 2013

13 The strength of small: Improved targeting of Insulin-like Growth Factor-1 Receptor (IGF-1R) with F(ab')2-R1507 fragments in Ewing sarcomas European Journal of Cancer, May 14, 2013

14 Carcinosarcoma of the liver: report of a case Surgery Today, May 13, 2013 Review Article

15 Clinical report on transarterial neoadjuvant chemotherapy of malignant fibrous histiocytoma in soft tissue Clinical and Translational Oncology, May 2, 2013 Review Article

16 High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma Cancer Research, April 2, 2013

17 Antibody-dependent cell lysis by NK cells is preserved after sarcoma-induced inhibition of NK cell cytotoxicity Cancer Immunology, Immunotherapy, April 30, 2013

18 Targeting FoxM1 Effectively Retards p53-Null Lymphoma and Sarcoma Molecular Cancer Therapeutics, May 14, 2013

19 Galectin-1 (GAL-1) expression is a useful tool to differentiate between small cell osteosarcoma and Ewing sarcoma Virchows Archiv, May 22, 2013

20 ASS1 as a novel tumor suppressor gene in myxofibrosarcomas: aberrant loss via epigenetic dna methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance Clinical Cancer Research, May 24, 2013

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more

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Oncology - Soft Tissue/Sarcoma News & Articles

Articles

Clinical Pearls in Oncology

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

HCC risk increased in patients with AIDS

RAB25 is a prognostic marker for ovarian cancer

Most Popular Oncology Articles

Other Topics in Oncology