Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Oncology
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D Scott Cunningham MD, PhD
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21 A Disintegrin And Metalloproteinase 12 produced by tumour cells accelerates osteosarcoma tumour progression and associated osteolysis European Journal of Cancer, April 29, 2013 Clinical Article
22 Bioactive lipids S1P and C1P are pro-metastatic factors in human rhabdomyosarcomas cell lines, and their tissue level increases in response to radio/chemotherapy Molecular Cancer Research, April 29, 2013 Clinical Article
23 The Correlation Between Dose of Folinic Acid and Neurotoxicity in Children and Adolescents Treated for Osteosarcoma With High-dose Methotrexate (HDMTX): A Neuropsychological and Psychosocial Study Journal of Pediatric Hematology/Oncology, April 29, 2013 Clinical Article
24 Vincristine, Irinotecan, and Temozolomide for Treatment of Relapsed Alveolar Rhabdomyosarcoma Journal of Pediatric Hematology/Oncology, April 29, 2013 Clinical Article
25 Intra-abdominal primary monophasic synovial sarcoma with hemangiopericytoma-like areas Journal of Cancer Research and Therapeutics, April 29, 2013
26 Myxofibrosarcoma: prevalence and diagnostic value of the tail sign on magnetic resonance imaging Skeletal Radiology, April 26, 2013 Clinical Article
27 Sorafenib in patients with progressive epithelioid hemangioendothelioma Cancer, April 25, 2013 Clinical Article
28 Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Childrens Oncology Group phase 1 consortium study The Lancet Oncology, April 24, 2013
29 YWHAE rearrangement identified by FISH and RT-PCR in endometrial stromal sarcomas: genetic and pathological correlations Modern Pathology, April 23, 2013 Clinical Article
30 microRNAs in uterine sarcomas and mixed epithelial-mesenchymal uterine tumors: a preliminary report Tumor Biology, April 23, 2013 Clinical Article
31 Tubulin-beta-III overexpression by uterine serous carcinomas is a marker for poor overall survival after platinum/taxane chemotherapy and sensitivity to epothilones Cancer, April 22, 2013 Clinical Article
32 Osteosarcoma of the spine: surgical treatment and outcomes Full Text World Journal of Surgical Oncology, April 22, 2013 Clinical Article
33 Intra-articular synovial sarcoma Skeletal Radiology, April 22, 2013
34 Fusion of the ZC3H7B and BCOR genes in endometrial stromal sarcomas carrying an X;22-translocation Genes, Chromosomes and Cancer, April 19, 2013 Clinical Article
35 Nonmucinous Cystadenomas of the Pancreas With Pancreatobiliary Phenotype and Ovarian-Like Stroma American Journal of Clinical Pathology, April 19, 2013 Clinical Article
36 Influence of Resident Education in Correctly Diagnosing Extremity Soft Tissue Sarcoma Sarcoma, April 19, 2013 Clinical Article
37 Matrine inhibited the growth of rat osteosarcoma UMR-108 cells by inducing apoptosis in a mitochondrial-caspase-dependent pathway Tumor Biology, April 18, 2013 Clinical Article
38 A systematic review of vascular endothelial growth factor expression as a biomarker of prognosis in patients with osteosarcoma Tumor Biology, April 18, 2013 Review Article Clinical Article
39 Targeting PI3K/Akt represses Hypoxia inducible factor-1alpha activation and sensitizes Rhabdomyosarcoma and Ewings sarcoma cells for apoptosis Cancer Cell International, April 18, 2013 Clinical Article
40 Elevated TNFR1 and serotonin in bone metastasis are correlated with poor survival following bone metastasis diagnosis for both carcinoma and sarcoma primary tumors Clinical Cancer Research, April 17, 2013 Clinical Article
As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.
Read the article summaryAs reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.
Read the article summaryAs reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.
Read the article summary1 High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma Cancer Research, April 2, 2013
2 Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma Journal of Clinical Oncology, April 15, 2013
3 Sorafenib in patients with progressive epithelioid hemangioendothelioma Cancer, April 25, 2013
4 Diagnostic accuracy of 18F-FDG PET/CT for detecting recurrence in patients with primary skeletal Ewing sarcoma European Journal of Nuclear Medicine & Molecular Imaging, April 9, 2013
5 Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial The Lancet Oncology, March 12, 2013
6 ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcoma: Aberrant loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance Clinical Cancer Research, April 8, 2013
7 Pulmonary Metastasectomy for Sarcoma of Gynaecologic Origin Heart, Lung, and Circulation, April 5, 2013
8 Preoperative and Therapeutic Embolization of Extremities of Bone and Soft Tissue Tumors Angiology, April 11, 2013
9 Head and neck soft tissue sarcomas: prognostic factors and outcome in a series of patients treated at a single institution Annals of Oncology, April 10, 2013
10 Targeted treatment for advanced soft tissue sarcoma: profile of pazopanib OncoTargets and Therapy, April 2, 2013 Free full text Review Article
11 Myxofibrosarcoma: prevalence and diagnostic value of the tail sign on magnetic resonance imaging Skeletal Radiology, April 26, 2013
12 The Combination of Sorafenib and Everolimus Abrogates mTORC1 and mTORC2 Upregulation in Osteosarcoma Preclinical Models Clinical Cancer Research, April 12, 2013
13 Do Malignant Bone Tumors of the Foot Have a Different Biological Behavior than Sarcomas at Other Skeletal Sites Sarcoma, April 1, 2013
14 Elevated preoperative neutrophil-lymphocyte ratio is associated with poor prognosis in soft-tissue sarcoma patients British Journal of Cancer, April 16, 2013
15 SRC Signaling Is Crucial in the Growth of Synovial Sarcoma Cells Cancer Research, April 17, 2013
16 Influence of Resident Education in Correctly Diagnosing Extremity Soft Tissue Sarcoma Sarcoma, April 19, 2013
17 Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells Oncogene, April 17, 2013
18 Expression of angiopoietin-TIE system components in angiosarcoma Modern Pathology, April 8, 2013
19 Distinct Effects of Ligand-Induced PDGFRα and PDGFRβ Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments Cancer Research, April 8, 2013
20 Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway Cancer Research, April 2, 2013
Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more
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