Oncology - Soft Tissue/Sarcoma News & Articles

Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.

On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (1) Full Text Articles (114) Focus on Neurologic

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

181 Sinonasal Teratocarcinosarcoma: A Clinical and Pathological Analysis International Journal of Surgical Pathology, January 18, 2013 Clinical Article

182 Molecular detection and targeting of EWSR1 fusion transcripts in soft tissue tumors Medical Oncology, January 18, 2013 Clinical Article

183 Dedifferentiated Liposarcoma With Lipoma-Like Well-Differentiated Liposarcoma Clinicopathological Study of 30 Cases, With Particular Attention to the Comingling Pattern of Well- and Dedifferentiated Components: A Proposal for Regrouping of the Present Subclassification of Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma International Journal of Surgical Pathology, January 17, 2013 Review Article

184 Anaplastic lymphoma kinase status in rhabdomyosarcomas Modern Pathology, January 15, 2013 Clinical Article

185 Characteristics and outcomes of patients with Ewing sarcoma over 40 years of age at diagnosis Cancer Epidemiology, January 14, 2013

186 The Molecular Biology of Soft-Tissue Sarcomas and Current Trends in Therapy Sarcoma, January 14, 2013 Clinical Article
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187 Phase I trial of bortezomib and dacarbazine in melanoma and soft tissue sarcoma Investigational New Drugs, January 14, 2013 Clinical Article

188 Merkel cell carcinoma with sarcomatous differentiation: is it a poor prognostic factor International Journal of Dermatology, January 8, 2013 Clinical Article

189 Radiation therapy target volume reduction in pediatric rhabdomyosarcoma Cancer, January 7, 2013 Clinical Article

190 Surgical resection with adjuvant brachytherapy in soft tissue sarcoma of the extremity – a case report Journal of Contemporary Brachytherapy, January 7, 2013

191 Surgical resection with adjuvant brachytherapy in soft tissue sarcoma of the extremity – a case report Journal of Contemporary Brachytherapy, January 4, 2013

192 Cyclophosphamide versus ifosfamide for paediatric and young adult bone and soft tissue sarcoma patients Cochrane Reviews, January 3, 2013 Clinical Article

193 Adult Orbital Myeloid Sarcoma (Granulocytic Sarcoma): Two Cases and Review of the Literature Orbit, January 3, 2013

194 Velaglucerase alfa enzyme replacement therapy compared with imiglucerase in patients with Gaucher disease American Journal of Hematology, December 31, 2012

195 Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02 Neuro-Oncology, December 21, 2012 Clinical Article

196 Well-differentiated and dedifferentiated liposarcomas with prominent myxoid stroma: analysis of 56 cases Histopathology, December 21, 2012

197 A unique pattern of INI1 immunohistochemistry distinguishes synovial sarcoma from its histologic mimics Human Pathology, December 21, 2012

198 Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion, resembling extraskeletal myxoid chondrosarcoma: Case report with a review of Literature Pathology International, December 20, 2012

199 Phase I and clinical pharmacology study of bevacizumab, sorafenib, and low-dose cyclophosphamide in children and young adults with refractory/recurrent solid tumors Clinical Cancer Research, December 19, 2012

200 Detection of HEY1-NCOA2 fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma Pathology International, December 18, 2012

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Clinical Pearls in Oncology

The ZORO study demonstrated that the addition of goserelin to neoadjuvant chemotherapy for early breast cancer in premenopausal women resulted in no change in post-chemotherapy rates of amenorrhea
A little over 50% of tumors in women with ER-positive, node-negative breast cancers will have a RS <18, and current data suggests that these women are UNLIKELY to receive a benefit from adjuvant chemotherapy
In patients with completely resected ER-positive DCIS when the surgical specimen also has LCIS, consider breast MRI screening in addition to mammography due to the lower sensitivity of mammograms for lobular disease

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.

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HCC risk increased in patients with AIDS

As reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.

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RAB25 is a prognostic marker for ovarian cancer

As reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.

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Most Popular Oncology Articles

Last month's top read Top Articles of 2012

1 High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma Cancer Research, April 2, 2013

2 Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma Journal of Clinical Oncology, April 15, 2013

3 Sorafenib in patients with progressive epithelioid hemangioendothelioma Cancer, April 25, 2013

4 Diagnostic accuracy of 18F-FDG PET/CT for detecting recurrence in patients with primary skeletal Ewing sarcoma European Journal of Nuclear Medicine & Molecular Imaging, April 9, 2013

5 Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial The Lancet Oncology, March 12, 2013

6 ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcoma: Aberrant loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance Clinical Cancer Research, April 8, 2013

7 Pulmonary Metastasectomy for Sarcoma of Gynaecologic Origin Heart, Lung, and Circulation, April 5, 2013

8 Preoperative and Therapeutic Embolization of Extremities of Bone and Soft Tissue Tumors Angiology, April 11, 2013

9 Head and neck soft tissue sarcomas: prognostic factors and outcome in a series of patients treated at a single institution Annals of Oncology, April 10, 2013

10 Targeted treatment for advanced soft tissue sarcoma: profile of pazopanib OncoTargets and Therapy, April 2, 2013 Free full text Review Article

11 Myxofibrosarcoma: prevalence and diagnostic value of the tail sign on magnetic resonance imaging Skeletal Radiology, April 26, 2013

12 The Combination of Sorafenib and Everolimus Abrogates mTORC1 and mTORC2 Upregulation in Osteosarcoma Preclinical Models Clinical Cancer Research, April 12, 2013

13 Do Malignant Bone Tumors of the Foot Have a Different Biological Behavior than Sarcomas at Other Skeletal Sites Sarcoma, April 1, 2013

14 Elevated preoperative neutrophil-lymphocyte ratio is associated with poor prognosis in soft-tissue sarcoma patients British Journal of Cancer, April 16, 2013

15 SRC Signaling Is Crucial in the Growth of Synovial Sarcoma Cells Cancer Research, April 17, 2013

16 Influence of Resident Education in Correctly Diagnosing Extremity Soft Tissue Sarcoma Sarcoma, April 19, 2013

17 Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells Oncogene, April 17, 2013

18 Expression of angiopoietin-TIE system components in angiosarcoma Modern Pathology, April 8, 2013

19 Distinct Effects of Ligand-Induced PDGFRα and PDGFRβ Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments Cancer Research, April 8, 2013

20 Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway Cancer Research, April 2, 2013

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more

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Oncology - Soft Tissue/Sarcoma News & Articles

Articles

Clinical Pearls in Oncology

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

HCC risk increased in patients with AIDS

RAB25 is a prognostic marker for ovarian cancer

Most Popular Oncology Articles

Other Topics in Oncology