Oncology - Pharmacology/Therapy News & Articles

Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.

On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (9) Full Text Articles (1643) Focus on Neurologic

Ranked, sorted, and summarized by MDLinx editors from the latest literature

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161 Phase II study of the Src kinase inhibitor saracatinib (AZD0530) in metastatic melanoma Investigational New Drugs, May 7, 2013 Clinical Article

162 Phase I study of pulsatile 3-day administration of afatinib (BIBW 2992) in combination with docetaxel in advanced solid tumors Investigational New Drugs, May 7, 2013 Clinical Article

163 A pilot study for the early assessment of the effects of BMS-754807 plus gefitinib in an H292 tumor model by [18F]fluorothymidine-positron emission tomography Investigational New Drugs, May 7, 2013 Clinical Article

164 A phase I study of IMP321 and gemcitabine as the front-line therapy in patients with advanced pancreatic adenocarcinoma Investigational New Drugs, May 7, 2013 Clinical Article

165 A phase II study of bevacizumab in combination with vinorelbine and trastuzumab in HER2-positive metastatic breast cancer Breast Cancer Research and Treatment, May 7, 2013 Clinical Article

166 CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity Clinical Cancer Research, May 7, 2013 Clinical Article

167 Activation of the PI3K/AKT/mTOR pathway in diffuse large B cell lymphoma: clinical significance and inhibitory effect of rituximab Annals of Hematology, May 7, 2013 Clinical Article

168 Increased Plasma Caveolin-1 Levels Are Associated with Progression of Prostate Cancer among Japanese Men Anticancer Research, May 7, 2013 Review Article Clinical Article

169 Denosumab and Anti-angiogenetic Drug-related Osteonecrosis of the Jaw: An Uncommon but Potentially Severe Disease Anticancer Research, May 7, 2013 Review Article Clinical Article

170 Ex vivo analysis of pancreatic cancer-infiltrating T lymphocytes reveals that ENO-specific Tregs accumulate in tumor tissue and inhibit Th1/Th17 effector cell functions Cancer Immunology, Immunotherapy, May 7, 2013 Clinical Article

171 Soluble interleukin-6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy Cancer Science, May 7, 2013 Clinical Article

172 Results of a 7-day aprepitant schedule for the prevention of nausea and vomiting in 5-day cisplatin-based germ cell tumor chemotherapy Supportive Care in Cancer, May 7, 2013 Clinical Article
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173 Predictive factors of response and survival among chronic myelomonocytic leukemia patients treated with azacitidine Leukemia Research, May 7, 2013 Clinical Article

174 IGF-1R targeting increases the antitumor effects of DNA damaging agents in SCLC model: an opportunity to increase the efficacy of standard therapy Molecular Cancer Therapeutics, May 7, 2013 Clinical Article

175 Effect of gabapentin pretreatment on propofol consumption, hemodynamic variables, and postoperative pain relief in breast cancer surgery Acta Anaesthesiologica Taiwanica, May 7, 2013 Clinical Article

176 Randomised, placebo-controlled, double-blind, parallel-group phase III study evaluating aflibercept in patients receiving first-line treatment with gemcitabine for metastatic pancreatic cancer European Journal of Cancer, May 6, 2013 Clinical Article

177 A comparative analysis of paediatric dose-finding trials of molecularly targeted agent with adults trials European Journal of Cancer, May 6, 2013 Clinical Article

178 Intensity-modulated radiotherapy (IMRT) in pediatric low-grade glioma Cancer, May 6, 2013 Clinical Article

179 miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma Cancer Research, May 6, 2013 Clinical Article

180 Real-World Effectiveness of Systemic Agents Approved for Advanced Non-Small Cell Lung Cancer: A SEER-Medicare Analysis Full Text The Oncologist, May 6, 2013 Clinical Article

50 available pages First Previous 9 10 11 12 13 14 15 16 17 18 Next Last

Clinical Pearls in Oncology

The ZORO study demonstrated that the addition of goserelin to neoadjuvant chemotherapy for early breast cancer in premenopausal women resulted in no change in post-chemotherapy rates of amenorrhea
A little over 50% of tumors in women with ER-positive, node-negative breast cancers will have a RS <18, and current data suggests that these women are UNLIKELY to receive a benefit from adjuvant chemotherapy
In patients with completely resected ER-positive DCIS when the surgical specimen also has LCIS, consider breast MRI screening in addition to mammography due to the lower sensitivity of mammograms for lobular disease

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.

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HCC risk increased in patients with AIDS

As reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.

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RAB25 is a prognostic marker for ovarian cancer

As reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.

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Most Popular Oncology Articles

Last month's top read Top Articles of 2012

1 Enalapril And Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients with Malignant Hemopathies. The OVERCOME Trial JACC - Journal of the American College of Cardiology, April 12, 2013

2 Bendamustine compared to fludarabine as second-line treatment in chronic lymphocytic leukemia Annals of Hematology, April 9, 2013

3 A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases Clinical Cancer Research, April 5, 2013

4 Controversies of the Hormonal Conservative Treatment of Endometrial Cancer Gynecologic and Obstetric Investigation, April 12, 2013 Review Article

5 The effect of imatinib therapy on the outcome of allogeneic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia Hematology, March 14, 2013

6 Efficacy and safety of weekly nab-paclitaxel plus carboplatin in patients with advanced non-small cell lung cancer Lung Cancer, April 3, 2013

7 Successful treatment by azacitidine therapy of intestinal Behçets disease associated with myelodysplastic syndrome International Journal of Hematology, April 2, 2013

8 Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of China Cancer, April 12, 2013

9 Phase III, Multicenter, Randomized Trial of Maintenance Chemotherapy Versus Observation in Patients With Metastatic Breast Cancer After Achieving Disease Control With Six Cycles of Gemcitabine Plus Paclitaxel As First-Line Chemotherapy: KCSG-BR07-02 Journal of Clinical Oncology, April 11, 2013

10 Mammographic Breast Density Response to Aromatase Inhibition Clinical Cancer Research, March 13, 2013

11 A review of iniparib in ovarian cancer Expert Opinion on Investigational Drugs, March 14, 2013

12 Continuous treatment with new agents for newly diagnosed multiple myeloma Anti-Cancer Drugs, April 9, 2013 Evidence Based Medicine Review Article

13 Analysis of Treatment Outcomes of Intraventricular Chemotherapy in 105 Patients for Leptomeningeal Carcinomatosis from Non-Small-Cell Lung Cancer Journal of Thoracic Oncology, April 18, 2013

14 Intrathecal administration of trastuzumab for the treatment of meningeal carcinomatosis in HER2-positive metastatic breast cancer: a systematic review and pooled analysis Breast Cancer Research and Treatment, April 18, 2013

15 Clinical Analysis of Gefitinib in the Treatment of Stage IV Lung Adenocarcinoma with Unknown EGFR Gene Mutations Thoracic Cancer, April 5, 2013

16 Phase III, randomized, placebo-controlled study of docetaxel in combination with zibotentan in patients with metastatic castration-resistant prostate cancer Journal of Clinical Oncology, April 11, 2013

17 Concomitant chemoradiotherapy with docetaxel and cisplatin followed by consolidation chemotherapy in locally advanced unresectable non-small cell lung cancer Annals of Thoracic Medicine, April 2, 2013 Free full text

18 Tumor response and health-related quality of life in clinically selected patients from Asia with advanced non-small-cell lung cancer treated with first-line gefitinib: Post hoc analyses from the IPASS study Lung Cancer, April 1, 2013

19 The changing paradigm of CLL management European Journal of Internal Medicine , April 17, 2013 Review Article

20 90Yttrium-Ibritumomab Tiuxetan Consolidation of First Remission in Advanced-Stage Follicular Non-Hodgkin Lymphoma: Updated Results After a Median Follow-Up of 7.3 Years From the International, Randomized, Phase III First-Line Indolent Trial Journal of Clinical Oncology, April 4, 2013

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more

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Oncology - Pharmacology/Therapy News & Articles

Articles

Clinical Pearls in Oncology

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

HCC risk increased in patients with AIDS

RAB25 is a prognostic marker for ovarian cancer

Most Popular Oncology Articles

Other Topics in Oncology