Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Oncology
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801 Mannitol improves cerebral oxygen content and postoperative recovery after prolonged retroperitoneal laparoscopy Surgical Endoscopy, March 29, 2013 Clinical Article
802 All-oral combination of vinorelbine and capecitabine as first-line treatment in HER2/Neu-negative metastatic breast cancer Cancer Chemotherapy and Pharmacology, March 28, 2013 Clinical Article
803 A randomized phase II study of gemcitabine and S-1 combination therapy versus gemcitabine monotherapy for advanced biliary tract cancer Cancer Chemotherapy and Pharmacology, March 28, 2013 Clinical Article
804 Phase I and pharmacokinetic study of gefitinib and S-1 combination therapy for advanced adenocarcinoma of the lung Cancer Chemotherapy and Pharmacology, March 28, 2013 Clinical Article
805 Effect of low-dose supplements of menaquinone-7 [vitamin K2(35)] on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers Journal of Thrombosis and Haemostasis, March 28, 2013 Clinical Article
806 The Influence of Phenothiazine Derivatives on Intracellular Accumulation of Cationic Cyanine Dye DiOC6(3) in LoVo-DX Cells Anticancer Research, March 28, 2013 Clinical Article
807 Immune thrombocytopenia in patients with chronic lymphocytic leukemia treated with cladribine-based regiments or chlorambucil - follow-up of PALG-CLL randomized trials European Journal of Haematology, March 28, 2013 Clinical Article
808 Use of tranexamic acid results in decreased blood loss and decreased transfusions in patients undergoing staged bilateral total knee arthroplasty Transfusion, March 28, 2013 Clinical Article
809 Mechanism of the antitumoral activity of deferasirox, an iron chelation agent, on mantle cell lymphoma Leukemia and Lymphoma, March 28, 2013 Clinical Article
810 Pharmacokinetics and efficacy of pemetrexed in patients with brain or leptomeningeal metastases Journal of Neuro-Oncology, March 28, 2013 Clinical Article
811 Gliomatosis cerebri: clinical characteristics, management, and outcomes Journal of Neuro-Oncology, March 28, 2013 Review Article Clinical Article
812 Erythropoietin treatment in chemotherapy-induced anemia in previously untreated advanced esophagogastric cancer patients International Journal of Clinical Oncology, March 28, 2013 Clinical Article
813 New targets for the immunotherapy of colon cancer—does reactive disease hold the answer Cancer Gene Therapy, March 28, 2013 Clinical Article
814 Targeting 20-HETE producing enzymes in cancer – rationale, pharmacology, and clinical potential Full Text OncoTargets and Therapy, March 28, 2013 Clinical Article
815 Gene therapy in B-NHL cell line using adenovirus-mediated transfer of secretable trimeric TRAIL gene expression driven by CD20 promoter Experimental Hematology, March 28, 2013 Clinical Article
816 Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy Clinical and Experimental Dermatology, March 28, 2013 Clinical Article
817 Propranolol therapy of infantile hemangiomas: efficacy, adverse effects, and recurrence Pediatric Surgery International, March 28, 2013 Clinical Article
818 Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT-0116/SWOG9008 clinical trial Annals of Oncology, March 27, 2013 Clinical Article
819 Dasatinib plus Capecitabine for Advanced Breast Cancer: Safety and Efficacy in Phase I Study CA180004 Clinical Cancer Research, March 27, 2013 Clinical Article
820 Advanced soft-tissue sarcoma in elderly patients: patterns of care and survival Annals of Oncology, March 27, 2013 Review Article
As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.
Read the article summaryAs reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.
Read the article summaryAs reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.
Read the article summary1 Enalapril And Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients with Malignant Hemopathies. The OVERCOME Trial JACC - Journal of the American College of Cardiology, April 12, 2013
2 Bendamustine compared to fludarabine as second-line treatment in chronic lymphocytic leukemia Annals of Hematology, April 9, 2013
3 A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases Clinical Cancer Research, April 5, 2013
4 Controversies of the Hormonal Conservative Treatment of Endometrial Cancer Gynecologic and Obstetric Investigation, April 12, 2013 Review Article
5 The effect of imatinib therapy on the outcome of allogeneic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia Hematology, March 14, 2013
6 Efficacy and safety of weekly nab-paclitaxel plus carboplatin in patients with advanced non-small cell lung cancer Lung Cancer, April 3, 2013
7 Successful treatment by azacitidine therapy of intestinal Behçets disease associated with myelodysplastic syndrome International Journal of Hematology, April 2, 2013
8 Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of China Cancer, April 12, 2013
9 Phase III, Multicenter, Randomized Trial of Maintenance Chemotherapy Versus Observation in Patients With Metastatic Breast Cancer After Achieving Disease Control With Six Cycles of Gemcitabine Plus Paclitaxel As First-Line Chemotherapy: KCSG-BR07-02 Journal of Clinical Oncology, April 11, 2013
10 Mammographic Breast Density Response to Aromatase Inhibition Clinical Cancer Research, March 13, 2013
11 A review of iniparib in ovarian cancer Expert Opinion on Investigational Drugs, March 14, 2013
12 Continuous treatment with new agents for newly diagnosed multiple myeloma Anti-Cancer Drugs, April 9, 2013 Evidence Based Medicine Review Article
13 Analysis of Treatment Outcomes of Intraventricular Chemotherapy in 105 Patients for Leptomeningeal Carcinomatosis from Non-Small-Cell Lung Cancer Journal of Thoracic Oncology, April 18, 2013
14 Intrathecal administration of trastuzumab for the treatment of meningeal carcinomatosis in HER2-positive metastatic breast cancer: a systematic review and pooled analysis Breast Cancer Research and Treatment, April 18, 2013
15 Clinical Analysis of Gefitinib in the Treatment of Stage IV Lung Adenocarcinoma with Unknown EGFR Gene Mutations Thoracic Cancer, April 5, 2013
16 Phase III, randomized, placebo-controlled study of docetaxel in combination with zibotentan in patients with metastatic castration-resistant prostate cancer Journal of Clinical Oncology, April 11, 2013
17 Concomitant chemoradiotherapy with docetaxel and cisplatin followed by consolidation chemotherapy in locally advanced unresectable non-small cell lung cancer Annals of Thoracic Medicine, April 2, 2013 Free full text
18 Tumor response and health-related quality of life in clinically selected patients from Asia with advanced non-small-cell lung cancer treated with first-line gefitinib: Post hoc analyses from the IPASS study Lung Cancer, April 1, 2013
19 The changing paradigm of CLL management European Journal of Internal Medicine , April 17, 2013 Review Article
20 90Yttrium-Ibritumomab Tiuxetan Consolidation of First Remission in Advanced-Stage Follicular Non-Hodgkin Lymphoma: Updated Results After a Median Follow-Up of 7.3 Years From the International, Randomized, Phase III First-Line Indolent Trial Journal of Clinical Oncology, April 4, 2013
Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more
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