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Oncology - Pharmacology/Therapy News & Articles

Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.

On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (9) Full Text Articles (1643) Focus on Breast
Ranked, sorted, and summarized by MDLinx editors from the latest literature
Topics:

61 Anti-cancer effects of newly developed chemotherapeutic agent, glycoconjugated palladium (II) complex, against cisplatin-resistant gastric cancer cells Full Text BMC Cancer, May 16, 2013    Clinical Article

62 Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway Carcinogenesis, May 16, 2013    Clinical Article

63 Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia European Journal of Clinical Pharmacology, May 16, 2013    Clinical Article

64 The roles of epigenetic modifications of proapoptotic BID and BIM genes in imatinib-resistant chronic myeloid leukemia cells Hematology, May 16, 2013    Clinical Article

65 Treatment With Topotecan Plus Cyclophosphamide in Children With First Relapse of Neuroblastoma Pediatric Blood & Cancer, May 16, 2013    Clinical Article

66 Is There a Possibility of a Cure in Patients With Colorectal Peritoneal Carcinomatosis Amenable to Complete Cytoreductive Surgery and Intraperitoneal Chemotherapy? Annals of Surgery, May 16, 2013    Clinical Article

67 Phase I trial, pharmacokinetics, and pharmacodynamics of vandetanib and dasatinib in children with newly diagnosed diffuse intrinsic pontine glioma Clinical Cancer Research, May 15, 2013    Clinical Article

68 Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer Cancer Chemotherapy and Pharmacology, May 15, 2013    Clinical Article

69 A phase II study of modified dose-dense paclitaxel and every 4-week carboplatin for the treatment of advanced-stage primary epithelial ovarian, fallopian tube, or peritoneal carcinoma Cancer Chemotherapy and Pharmacology, May 15, 2013    Clinical Article

70 Clinical perspective of afatinib in non-small cell lung cancer Lung Cancer, May 15, 2013    Review Article

71 Correlation between response to chemotherapy with concomitant bevacizumab for hepatic metastasis of colorectal cancer and degree of enhancement using contrast-enhanced computed tomography Cancer Chemotherapy and Pharmacology, May 15, 2013    Clinical Article

72 Clinical features and outcome of leptomeningeal metastasis in patients with breast cancer: a single center experience Cancer Chemotherapy and Pharmacology, May 15, 2013    Clinical Article

73 Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer Cancer Treatment Reviews, May 15, 2013    Review Article    Clinical Article

74 Concurrent sunitinib and stereotactic body radiotherapy for patients with oligometastases Targeted Oncology, May 15, 2013    Clinical Article

75 Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors Clinical Cancer Research, May 15, 2013    Clinical Article

76 Inhibition of Histone Demethylase JMJD1A Improves Anti-Angiogenic Therapy and Reduces Tumor-Associated Macrophages Cancer Research, May 15, 2013    Clinical Article

77 Center of Cancer Systems Biology Second Annual Workshop—Tumor Metronomics: Timing and Dose Level Dynamics Cancer Research, May 15, 2013    Clinical Article

78 Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells Cancer Immunology, Immunotherapy, May 15, 2013    Clinical Article

79 Late-onset Pneumocystis jirovecii pneumonia post fludarabine, cyclophosphamide and rituximab: implications for prophylaxis European Journal of Haematology, May 15, 2013    Review Article

80 Sensitivity and resistance of JAK2 inhibitors to myeloproliferative neoplasms International Journal of Hematology, May 15, 2013    Clinical Article

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Clinical Pearls in Oncology

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.

Read the article summary

HCC risk increased in patients with AIDS

As reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.

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RAB25 is a prognostic marker for ovarian cancer

As reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.

Read the article summary

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Most Popular Oncology Articles

Last month's top read Top Articles of 2012

1 Enalapril And Carvedilol for Preventing Chemotherapy-Induced Left Ventricular Systolic Dysfunction in Patients with Malignant Hemopathies. The OVERCOME Trial JACC - Journal of the American College of Cardiology, April 12, 2013

2 Bendamustine compared to fludarabine as second-line treatment in chronic lymphocytic leukemia Annals of Hematology, April 9, 2013

3 A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases Clinical Cancer Research, April 5, 2013

4 Controversies of the Hormonal Conservative Treatment of Endometrial Cancer Gynecologic and Obstetric Investigation, April 12, 2013    Review Article

5 The effect of imatinib therapy on the outcome of allogeneic stem cell transplantation in adults with Philadelphia chromosome-positive acute lymphoblastic leukemia Hematology, March 14, 2013

6 Efficacy and safety of weekly nab-paclitaxel plus carboplatin in patients with advanced non-small cell lung cancer Lung Cancer, April 3, 2013

7 Successful treatment by azacitidine therapy of intestinal Behçets disease associated with myelodysplastic syndrome International Journal of Hematology, April 2, 2013

8 Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of China Cancer, April 12, 2013

9 Phase III, Multicenter, Randomized Trial of Maintenance Chemotherapy Versus Observation in Patients With Metastatic Breast Cancer After Achieving Disease Control With Six Cycles of Gemcitabine Plus Paclitaxel As First-Line Chemotherapy: KCSG-BR07-02 Journal of Clinical Oncology, April 11, 2013

10 Mammographic Breast Density Response to Aromatase Inhibition Clinical Cancer Research, March 13, 2013

11 A review of iniparib in ovarian cancer Expert Opinion on Investigational Drugs, March 14, 2013

12 Continuous treatment with new agents for newly diagnosed multiple myeloma Anti-Cancer Drugs, April 9, 2013    Evidence Based Medicine    Review Article

13 Analysis of Treatment Outcomes of Intraventricular Chemotherapy in 105 Patients for Leptomeningeal Carcinomatosis from Non-Small-Cell Lung Cancer Journal of Thoracic Oncology, April 18, 2013

14 Intrathecal administration of trastuzumab for the treatment of meningeal carcinomatosis in HER2-positive metastatic breast cancer: a systematic review and pooled analysis Breast Cancer Research and Treatment, April 18, 2013

15 Clinical Analysis of Gefitinib in the Treatment of Stage IV Lung Adenocarcinoma with Unknown EGFR Gene Mutations Thoracic Cancer, April 5, 2013

16 Phase III, randomized, placebo-controlled study of docetaxel in combination with zibotentan in patients with metastatic castration-resistant prostate cancer Journal of Clinical Oncology, April 11, 2013

17 Concomitant chemoradiotherapy with docetaxel and cisplatin followed by consolidation chemotherapy in locally advanced unresectable non-small cell lung cancer Annals of Thoracic Medicine, April 2, 2013    Free full text

18 Tumor response and health-related quality of life in clinically selected patients from Asia with advanced non-small-cell lung cancer treated with first-line gefitinib: Post hoc analyses from the IPASS study Lung Cancer, April 1, 2013

19 The changing paradigm of CLL management European Journal of Internal Medicine , April 17, 2013    Review Article

20 90Yttrium-Ibritumomab Tiuxetan Consolidation of First Remission in Advanced-Stage Follicular Non-Hodgkin Lymphoma: Updated Results After a Median Follow-Up of 7.3 Years From the International, Randomized, Phase III First-Line Indolent Trial Journal of Clinical Oncology, April 4, 2013

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncologymore

Other Topics in Oncology

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