Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Oncology
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D Scott Cunningham MD, PhD
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941 Genetic Variations in TGF β1, tPA, and ACE and Radiation-Induced Thoracic Toxicities in Patients with Non-Small-Cell Lung Cancer Journal of Thoracic Oncology, January 21, 2013 Clinical Article
942 Patterns of Failure after Stereotactic Body Radiation Therapy or Lobar Resection for Clinical Stage I Non-Small-Cell Lung Cancer Journal of Thoracic Oncology, January 21, 2013 Clinical Article
943 The Presence of Mutations in Epidermal Growth Factor Receptor Gene Is Not a Prognostic Factor for Long-Term Outcome after Surgical Resection of Non-Small-Cell Lung Cancer Journal of Thoracic Oncology, January 21, 2013 Clinical Article
944 Protocadherin 10 is frequently downregulated by promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer Cancer Biomarkers, January 21, 2013 Clinical Article
945 Patterns of Failure, Toxicity, and Survival after Extrapleural Pneumonectomy and Hemithoracic Intensity-Modulated Radiation Therapy for Malignant Pleural Mesothelioma Journal of Thoracic Oncology, January 21, 2013 Clinical Article
946 Prognostic value of COX-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis Full Text Journal of Thoracic Disease, January 21, 2013 Evidence Based Medicine
947 Is overall survival still the primary endpoint in maintenance non-small cell lung cancer studies? An analysis of phase III randomised trials Full Text Translational Lung Cancer Research, January 21, 2013 Review Article
948 Treatment of Leptomeningeal Spread of NSCLC - A Continuing Challenge Current Treatment Options in Oncology, January 21, 2013 Clinical Article
949 Angiogenesis, multitarget kinase inhibitors and non-small cell lung cancer: a lesson from MONET1 trial Full Text Translational Lung Cancer Research, January 21, 2013 Clinical Article
950 High prevalence of gene abnormalities in young patients with lung cancer Full Text Journal of Thoracic Disease, January 21, 2013 Clinical Article
951 Mir-186 downregulation correlates with poor survival in lung adenocarcinoma, where it interferes with cell-cycle regulation Cancer Research, January 21, 2013 Review Article
952 HNF4(alpha) as a Marker for Invasive Mucinous Adenocarcinoma of the Lung American Journal of Surgical Pathology , January 21, 2013 Clinical Article
953 Spheroid Culture of Primary Lung Cancer Cells with Neuregulin 1/HER3 Pathway Activation Journal of Thoracic Oncology, January 21, 2013 Review Article
954 High COL4A3 expression correlates with poor prognosis after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer Tumor Biology, January 21, 2013 Clinical Article
955 The expression and function of microRNA-203 in lung cancer Tumor Biology, January 21, 2013 Clinical Article
956 A retrospective analysis of survival outcomes for two different radiotherapy fractionation schedules given in the same overall time for limited stage small cell lung cancer Journal of Medical Imaging and Radiation Oncology, January 21, 2013 Clinical Article
957 Phase II trial of neoadjuvant pemetrexed plus cisplatin followed by surgery and radiation in the treatment of pleural mesothelioma Full Text BMC Cancer, January 18, 2013
958 Surgical treatment of early stage small cell lung cancer Asian Cardiovascular and Thoracic Annals, January 18, 2013
959 Molecular dissection of AKT activation in lung cancer cell lines Molecular Cancer Research, January 18, 2013 Clinical Article
960 Strategies for Overcoming EGFR Resistance in the Treatment of Advanced-Stage NSCLC Current Treatment Options in Oncology, January 18, 2013 Clinical Article
As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.
Read the article summaryAs reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.
Read the article summaryAs reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.
Read the article summary1 Radiotherapy for lung tumors arising after a prior pneumonectomy Journal of Thoracic Disease, April 8, 2013 Free full text
2 Comparative effectiveness of three platinum-doublet chemotherapy regimens in elderly patients with advanced non-small cell lung cancer Cancer, April 10, 2013
3 Impact of EGFR Inhibitor in Non-Small Cell Lung Cancer on Progression-Free and Overall Survival: A Meta-Analysis Journal of the National Cancer Institute, April 19, 2013 Evidence Based Medicine
4 Prediagnosis soy food consumption and lung cancer survival in women Journal of Clinical Oncology, April 1, 2013
5 Thymidylate synthase and ERCC1 as predictive markers in patients with pulmonary adenocarcinoma treated with pemetrexed and cisplatin Lung Cancer, April 2, 2013
6 Thalidomide versus active supportive care for maintenance in patients with malignant mesothelioma after first-line chemotherapy (NVALT 5): an open-label, multicentre, randomised phase 3 study The Lancet Oncology, April 18, 2013
7 The effectiveness of erlotinib against brain metastases in non-small cell lung cancer patients American Journal of Clinical Oncology, March 28, 2013
8 Diabetes mellitus as an independent risk factor for lung cancer: A meta-analysis of observational studies European Journal of Cancer, April 11, 2013 Review Article
9 Efficacy and safety of albumin-bound paclitaxel in treating recurrent advanced non-small-cell lung cancer Chinese Journal of Cancer Research, April 16, 2013 Free full text
10 Vimentin expression predicts the occurrence of metastases in non small cell lung carcinomas Lung Cancer, April 12, 2013
11 Effects of erlotinib first-line maintenance therapy versus placebo on the health-related quality of life of patients with metastatic non-small-cell lung cancer European Journal of Cancer, March 18, 2013
12 A multicenter Phase II study of ganetespib monotherapy in patients with genotypically-defined advanced non-small cell lung cancer Clinical Cancer Research, April 9, 2013
13 Novel therapeutic targets in non-small cell lung cancer Current Opinion in Pharmacology , April 29, 2013 Review Article
14 Prospective, multicenter, randomized, independent-group, open-label phase II study to investigate the efficacy and safety of three regimens with two doses of sagopilone as second-line therapy in patients with stage IIIB or IV non-small-cell lung cancer Lung Cancer, April 2, 2013
15 Treatment of stage IIIb/IV non-small cell lung cancer with Pemetrexed plus Oxaliplatin after failure of Erlotinib as second-line treatment Medical Oncology, April 15, 2013
16 The use of fused PET/CT images for patient selection and radical radiotherapy target volume definition in patients with non-small cell lung cancer: Results of a prospective study with mature survival data Radiotherapy & Oncology, April 4, 2013
17 Randomized phase II study of ixabepilone or paclitaxel plus carboplatin in patients with non-small-cell lung cancer prospectively stratified by beta-3 tubulin status Journal of Clinical Oncology, April 25, 2013
18 Cruciferous vegetables consumption and the risk of female lung cancer: a prospective study and a meta-analysis Annals of Oncology, April 9, 2013 Review Article
19 The prognostic and predictive value of KRAS oncogene substitutions in lung adenocarcinoma Cancer, March 26, 2013
20 Mutation analysis of the EGFR gene and downstream signalling pathway in histologic samples of malignant pleural mesothelioma British Journal of Cancer, April 8, 2013
Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more
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