Oncology - Coagulation/Bleeding Dz News & Articles

Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.

On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (4) Full Text Articles (120) Focus on Bone

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

401 Clinical and prognostic significance of coagulation assays in melanoma Melanoma Research, September 28, 2012 Clinical Article

402 Skeletal and extraskeletal manifestations of mixed alpha and beta thalassemia Radiology Case Reports, September 28, 2012

403 CYP2C9 and VKORC1 polymorphisms influence warfarin dose variability in patients on long-term anticoagulation European Journal of Clinical Pharmacology, September 26, 2012 Clinical Article

404 Levels of prolactin in relation to coagulation factors and risk of venous thrombosis Thrombosis and Haemostasis, September 20, 2012

405 Thrombocytopenia in Relation to Tumor Size in Patients with Hepatocellular Carcinoma Oncology, September 19, 2012

406 Immune thrombocytopenia in the elderly: clinical course in 525 patients from a single center in China Annals of Hematology, September 19, 2012

407 Increased Serum Heat Shock Protein 27 Antibody Titers and Prooxidant-Antioxidant Balance in Patients with Beta-Thalassemia Major Acta Haematologica, September 13, 2012

408 Impact of multiple joint impairments on the energetics and mechanics of walking in patients with haemophilia Haemophilia, September 12, 2012

409 Status of 25-hydroxyvitamin D deficiency and effect of vitamin D receptor gene polymorphisms on bone mineral density in thalassemia patients of North India Hematology, September 10, 2012 Clinical Article

410 An evidence-based threshold for thrombocytopenia associated with clinically significant bleeding in pediatric intensive care unit patients Pediatric Critical Care, September 10, 2012 Evidence Based Medicine

411 Accuracy and safety of ⁹⁹mTc-labeled anti-D-dimer (DI-80B3) Fab' fragments (ThromboView) in the diagnosis of deep vein thrombosis: A phase II study Thrombosis Research, September 10, 2012 Clinical Article

412 The clinical significance of circulating B cells secreting anti-glycoprotein IIb/IIIa antibody and platelet glycoprotein IIb/IIIa in patients with primary immune thrombocytopenia Hematology, September 7, 2012

413 Decreased expression of indoleamine 2,3-dioxygenase 1 in dendritic cells contributes to impaired regulatory T cell development in immune thrombocytopenia Annals of Hematology, September 6, 2012

414 The European Principles of Haemophilia Care: a pilot investigation of adherence to the principles in Europe Haemophilia, September 4, 2012

415 Immune tolerance in haemophilia: the long journey to the fork in the road British Journal of Haematology, August 31, 2012

416 Thrombocytopenia and platelet transfusion in UK critical care: a multicenter observational study Transfusion, August 31, 2012

417 Short-term low-dose secondary prophylaxis for severe/moderate haemophilia A children is beneficial to reduce bleed and improve daily activity, but there are obstacle in its execution: a multi-centre pilot study in China Haemophilia, August 31, 2012

418 Pathogen inactivation of platelets using ultraviolet C light: effect on in vitro function and recovery and survival of platelets Transfusion, August 31, 2012

419 Heparin-grafted dialysis membrane allows minimal systemic anticoagulation in regular hemodialysis patients: A prospective proof-of-concept study Hemodialysis International, August 28, 2012 Clinical Article

420 Comprehensive care of the patient with haemophilia and inhibitors undergoing surgery: practical aspects Haemophilia, August 28, 2012

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Clinical Pearls in Oncology

The ZORO study demonstrated that the addition of goserelin to neoadjuvant chemotherapy for early breast cancer in premenopausal women resulted in no change in post-chemotherapy rates of amenorrhea
A little over 50% of tumors in women with ER-positive, node-negative breast cancers will have a RS <18, and current data suggests that these women are UNLIKELY to receive a benefit from adjuvant chemotherapy
In patients with completely resected ER-positive DCIS when the surgical specimen also has LCIS, consider breast MRI screening in addition to mammography due to the lower sensitivity of mammograms for lobular disease

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.

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HCC risk increased in patients with AIDS

As reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.

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RAB25 is a prognostic marker for ovarian cancer

As reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.

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Most Popular Oncology Articles

Last month's top read Top Articles of 2012

1 Management and outcomes for patients with TTP: Analysis of 100 cases at a single institution American Journal of Hematology, April 29, 2013

2 Anticoagulation for prevention and treatment of cancer-related venous thromboembolism British Journal of Haematology, April 9, 2013

3 Adherence to anticoagulant treatment with dabigatran in a real-world setting Journal of Thrombosis and Haemostasis, April 19, 2013
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4 Impact of a venous thromboembolism (VTE) prophylaxis smart order set: Improved compliance, fewer events American Journal of Hematology, April 8, 2013

5 Bleeding risk in warfarinized patients with a therapeutic INR: the effect of low factor IX levels Journal of Thrombosis and Haemostasis, April 18, 2013

6 Intracranial haemorrhage in von Willebrand disease: a report on six cases Haemophilia, April 23, 2013

7 Advances in megakaryocytopoiesis and thrombopoiesis: from bench to bedside British Journal of Haematology, April 25, 2013 Review Article

8 ADAMTS13 unbound to larger von Willebrand factor multimers in cryosupernatant: implications for selection of plasma preparations for thrombotic thrombocytopenic purpura treatment Transfusion, April 10, 2013

9 Venous thromboembolism in adults treated for acute lymphoblastic leukaemia: Effect of fresh frozen plasma supplementation Thrombosis and Haemostasis, April 23, 2013

10 The predictive ability of bleeding risk stratification models in very old patients on VKA treatment for venous thromboembolism Results of the Prospective Collaborative EPICA study Journal of Thrombosis and Haemostasis, April 15, 2013

11 FcRIIa proteolysis as a diagnostic biomarker for heparin-induced thrombocytopenia Journal of Thrombosis and Haemostasis, April 3, 2013

12 Unresponsive thrombotic thrombocytopenic purpura in critically ill adults Intensive Care Medicine, April 5, 2013

13 Statin Therapy and Levels of Hemostatic Factors in a Healthy Population: the Multi-Ethnic Study of Atherosclerosis Journal of Thrombosis and Haemostasis, April 11, 2013

14 Post-thrombotic syndrome: a clinical review Journal of Thrombosis and Haemostasis, March 8, 2013 Review Article

15 Product-dependent anti-factor VIII antibodies Haemophilia, April 25, 2013

16 Anticoagulant use in patients with cancer associated venous thromboembolism: A retrospective cohort study Thrombosis Research, March 22, 2013 Evidence Based Medicine

17 Plasma concentration of protein Z and protein Z-dependent protease inhibitor in patients with haemophilia A Thrombosis Research, April 2, 2013 Evidence Based Medicine

18 Whole blood clots are more resistant to lysis than plasma clots - greater efficacy of rivaroxaban Thrombosis Research, April 2, 2013

19 Platelet size for distinguishing between inherited thrombocytopenias and immune thrombocytopenia: a multicentric, real life study British Journal of Haematology, April 26, 2013 Review Article

20 Successful percutaneous coronary intervention in a patient with combined deficiency of FV and FVIII due to novel compound heterozygous mutations in LMAN1 Haemophilia, April 11, 2013

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more

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Oncology - Coagulation/Bleeding Dz News & Articles

Articles

Clinical Pearls in Oncology

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

HCC risk increased in patients with AIDS

RAB25 is a prognostic marker for ovarian cancer

Most Popular Oncology Articles

Other Topics in Oncology