Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.
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981 A tumor hypoxic niche protects human colon cancer stem cells from chemotherapy Journal of Cancer Research & Clinical Oncology, January 21, 2013 Review Article
982 Venous Invasion in Colorectal Cancer: Impact of an Elastin Stain on Detection and Interobserver Agreement Among Gastrointestinal and Nongastrointestinal Pathologists American Journal of Surgical Pathology , January 21, 2013 Clinical Article
983 KiSS-1 methylation and protein expression patterns contribute to diagnostic and prognostic assessments in tissue specimens for colorectal cancer Tumor Biology, January 21, 2013 Clinical Article
984 Local colorectal cancer recurrence: pelvic MRI evaluation Abdominal Imaging , January 21, 2013 Clinical Article
985 TAGLN suppresses proliferation and invasion, and induces apoptosis of colorectal carcinoma cells Tumor Biology, January 21, 2013 Clinical Article
986 Tropomyosin receptor kinases B and C are tumor progressive and metastatic marker in colorectal carcinoma Human Pathology, January 18, 2013
987 Cost-Effectiveness of Adjuvant FOLFOX and 5FU/LV Chemotherapy for Patients with Stage II Colon Cancer Medical Decision Making, January 18, 2013 Clinical Article
988 A Phase II Study of High-Dose Cetuximab plus Irinotecan in Colorectal Cancer Patients with KRAS Wild-Type Tumors Who Progressed after Standard Dose of Cetuximab plus Irinotecan Oncology, January 18, 2013 Clinical Article
989 Comparison of intracorporeal single-stapled and double-stapled anastomosis in laparoscopic low anterior resection for rectal cancer: a case-control study International Journal of Colorectal Disease, January 18, 2013 Clinical Article
990 KRAS mutation analysis on low percentage of colon cancer cells: the importance of quality assurance Virchows Archiv, January 18, 2013 Clinical Article
991 SKP2 overexpression is associated with a poor prognosis of rectal cancer treated with chemoradiotherapy and represents a therapeutic target with high potential Tumor Biology, January 18, 2013 Clinical Article
992 The predictive role of skin rash with cetuximab and panitumumab in colorectal cancer patients: a systematic review and meta-analysis of published trials Targeted Oncology, January 18, 2013 Evidence Based Medicine Review Article Clinical Article
993 SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer Cancer Research, January 18, 2013 Clinical Article
994 Telomerase is an independent prognostic marker of overall survival in patients with colorectal cancer British Journal of Cancer, January 17, 2013
995 Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in colorectal cancer patients International Journal of Cancer, January 17, 2013
996 An endoscopic quality improvement program improves detection of colorectal adenomas The American Journal of Gastroenterology, January 17, 2013 Clinical Article
997 Colonic Methane Production Modifies Gastrointestinal Toxicity Associated With Adjuvant 5-Fluorouracil Chemotherapy for Colorectal Cancer Journal of Clinical Gastroenterology, January 17, 2013 Clinical Article
998 Positive Expression of LSD1 and Negative Expression of E-cadherin Correlate with Metastasis and Poor Prognosis of Colon Cancer Digestive Diseases and Sciences, January 17, 2013 Clinical Article
999 SLIT2 inhibits cell migration in colorectal cancer through the AKT-GSK3β signaling pathway International Journal of Colorectal Disease, January 17, 2013 Clinical Article
1000 Quantitative profiling of CpG island methylation in human stool for colorectal cancer detection International Journal of Colorectal Disease, January 17, 2013 Clinical Article
As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.
Read the article summaryAs reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.
Read the article summaryAs reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.
Read the article summary1 The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer British Journal of Cancer, May 13, 2013
2 Clinical Prediction of Pathological Complete Response After Preoperative Chemoradiotherapy for Rectal Cancer Diseases of the Colon and Rectum, May 16, 2013
3 Risk factors for false positive and for false negative test results in screening with fecal occult blood testing International Journal of Cancer, May 7, 2013
4 Prognostic implication of mucinous histology in colorectal cancer patients treated with adjuvant FOLFOX chemotherapy British Journal of Cancer, May 13, 2013
5 FOLFOXIRI in combination with panitumumab as first-line treatment in quadruple wild-type (KRAS, NRAS, HRAS, BRAF) metastatic colorectal cancer patients: a phase II trial by the Gruppo Oncologico Nord Ovest (GONO) Annals of Oncology, May 14, 2013
6 Tankyrase Inhibitor Suppresses Colorectal Tumor Growth Cancer Research, May 13, 2013
7 Identification and validation of a blood-based 18-gene expression signature in colorectal cancer Clinical Cancer Research, May 13, 2013
8 Current opinion on optimal treatment for colorectal cancer Expert Review of Anticancer Therapy, May 14, 2013 Review Article
9 Multicenter validation study of pathologic response and tumor thickness at the tumor-normal liver interface as independent predictors of disease-free survival after preoperative chemotherapy and surgery for colorectal liver metastases Cancer, May 6, 2013
10 Is There a Possibility of a Cure in Patients With Colorectal Peritoneal Carcinomatosis Amenable to Complete Cytoreductive Surgery and Intraperitoneal Chemotherapy? Annals of Surgery, May 16, 2013
11
The Increased Risk of Colon Cancer Due to Cigarette Smoking May Be Greater in Women than Men
Cancer Epidemiology, Biomarkers & Prevention, May 6, 2013
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12 Surgery for Locally Advanced Recurrent Colorectal Cancer Involving the Aortoiliac Axis: Can We Achieve R0 Resection and Long-term Survival? Diseases of the Colon and Rectum, May 13, 2013
13 Current Status of Rectal Cancer Treatment in China Colorectal Disease, May 13, 2013 Review Article
14 Association between physical activity and mortality in colorectal cancer: A meta-analysis of prospective cohort studies International Journal of Cancer, April 22, 2013 Review Article
15 Hostmicrobiota interaction and intestinal stem cells in chronic inflammation and colorectal cancer Expert Review of Clinical Immunology, May 9, 2013
16 CCR4 mediates CCL17 (TARC)-induced migration of human colon cancer cells via RhoA/Rho-kinase signaling International Journal of Colorectal Disease, May 13, 2013 Review Article
17 Phase II trial of temsirolimus alone and in combination with irinotecan for KRAS mutant metastatic colorectal cancer: Outcome and results of KRAS mutational analysis in plasma Acta Oncologica, May 22, 2013
18 Superior diagnostic performance of faecal immunochemical tests for haemoglobin in a head-to-head comparison with guaiac based faecal occult blood test among 2235 participants of screening colonoscopy European Journal of Cancer, May 30, 2013
19 Prospective phase II study of neoadjuvant FOLFOX6 plus cetuximab in patients with colorectal cancer and unresectable liver-only metastasis Cancer Chemotherapy and Pharmacology, May 28, 2013
20 Tracking the Molecular Features of Nonpolypoid Colorectal Neoplasms: A Systematic Review and Meta-Analysis The American Journal of Gastroenterology, May 13, 2013
Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more
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