Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.
On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.
Your Unread Messages in Oncology
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21 MicroRNA-191, an estrogen-responsive microRNA, functions as an oncogenic regulator in human breast cancer Carcinogenesis, May 16, 2013 Clinical Article
22 Stiffness of tumours measured by shear-wave elastography correlated with subtypes of breast cancer European Radiology, May 16, 2013 Clinical Article
23 Clinical features and outcome of leptomeningeal metastasis in patients with breast cancer: a single center experience Cancer Chemotherapy and Pharmacology, May 15, 2013 Clinical Article
24 Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer Cancer Treatment Reviews, May 15, 2013 Review Article Clinical Article
25 Intermittent Calorie Restriction and EPA Inhibit Mammary Tumors Cancer Prevention Research, May 15, 2013 Clinical Article
26 Dietary Chemopreventative Benzyl Isothiocyanate Inhibits Breast Cancer Stem Cells In Vitro and In Vivo Cancer Prevention Research, May 15, 2013 Clinical Article
27 Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15 Breast Cancer Research, May 15, 2013 Clinical Article
28 Expression and sub-cellular localization of an epigenetic regulator, co-activator arginine methyltransferase 1 (CARM1), is associated with specific breast cancer subtypes and ethnicity Full Text Molecular Cancer, May 15, 2013 Clinical Article
29 Radioactive seed localisation (RSL) in the treatment of non-palpable breast cancers: Systematic review and meta-analysis The Breast, May 15, 2013 Evidence Based Medicine Review Article
30 Two surgeons, one patient: The impact of surgeon-surgeon familiarity on patient outcomes following mastectomy with immediate reconstruction The Breast, May 15, 2013 Clinical Article
31 Patient attitudes towards undergoing additional breast biopsy for research The Breast, May 15, 2013 Clinical Article
32 Anti-tumour activity of phosphoinositide-3-kinase antagonist AEZS 126 in models of triple-negative breast cancer Journal of Cancer Research & Clinical Oncology, May 15, 2013 Clinical Article
33 Targeting CXCR2 Enhances Chemotherapeutic Response, Inhibits Mammary Tumor Growth, Angiogenesis, and Lung Metastasis Molecular Cancer Therapeutics, May 15, 2013 Clinical Article
34 Meta-Analysis to Determine if Surgical Resection of the Primary Tumour in the Setting of Stage IV Breast Cancer Impacts on Survival Annals of Surgical Oncology, May 15, 2013 Clinical Article
35 Evaluation of Mucin-1 protein and mRNA expression as prognostic and predictive markers after neoadjuvant chemotherapy for breast cancer Annals of Oncology, May 14, 2013
36 Association between 8-oxo-7,8-dihydro-2-deoxyguanosine excretion and risk of postmenopausal breast cancer: nested case-control study Cancer Epidemiology, Biomarkers & Prevention, May 14, 2013
37 Using one-step nucleic acid amplification (OSNA) for intraoperative detection of lymph node metastasis in breast cancer patients avoids second surgery and accelerates initiation of adjuvant therapy Annals of Oncology, May 14, 2013 Clinical Article
38 Fatigue related to radiotherapy for breast and/or gynaecological cancer: a systematic review Journal of Clinical Nursing, May 14, 2013 Review Article
39 A case-control study of lifetime occupational sitting and likelihood of breast cancer Cancer Causes and Control, May 14, 2013 Clinical Article
40 Plasma Vitamin D levels, menopause, and risk of breast cancer: dose-response meta-analysis of prospective studies Medicine, May 14, 2013 Clinical Article
As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.
Read the article summaryAs reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.
Read the article summaryAs reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.
Read the article summary1 Radiotherapy or tamoxifen after conserving surgery for breast cancers of excellent prognosis: British Association of Surgical Oncology (BASO) II trial European Journal of Cancer, April 2, 2013
2 Effect of low-dose tamoxifen after surgical excision of ductal intraepithelial neoplasia: results of a large retrospective monoinstitutional cohort study Annals of Oncology, April 1, 2013
3 Increased pathological complete response rate after a long-term neoadjuvant letrozole treatment in postmenopausal oestrogen and/or progesterone receptor-positive breast cancer British Journal of Cancer, April 16, 2013
4 Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial The Lancet Oncology, March 12, 2013
5 Association of metformin use with cancer incidence and mortality: A meta-analysis Cancer Epidemiology, April 22, 2013 Review Article
6 Factors associated with surgical management following neoadjuvant therapy in patients with primary HER2-positive breast cancer: results from the NeoALTTO phase III trial Annals of Oncology, April 12, 2013
7 Neoadjuvant chemotherapy with paclitaxel and everolimus in breast cancer patients with non-responsive tumours to epirubicin/cyclophosphamide (EC)±bevacizumab: Results of the randomised GeparQuinto study (GBG 44) European Journal of Cancer, April 24, 2013
8 AVEREL: A randomized phase III trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer Journal of Clinical Oncology, April 15, 2013
9 Estrogen plus progestin and breast cancer incidence and mortality in the Women's Health Initiative Observational Study Journal of the National Cancer Institute, April 4, 2013
10 Analysis in early stage triple-negative breast cancer treated with mastectomy without adjuvant radiotherapy: Patterns of failure and prognostic factors Cancer, April 12, 2013
11 Effect of body mass index on tumor characteristics and disease-free survival in patients from the HER2-positive adjuvant trastuzumab trial N9831 Cancer, April 19, 2013
12 Randomised phase 3 open-label trial of first-line treatment with gemcitabine in association with docetaxel or paclitaxel in women with metastatic breast cancer: a comparison of different schedules and treatments BMC Cancer, April 3, 2013 Free full text
13 Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis The Lancet Oncology, April 9, 2013 Evidence Based Medicine Review Article
14 Magnitude of trastuzumab benefit in patients with HER2-positive, invasive lobular breast carcinoma: Results from the HERA Trial Journal of Clinical Oncology, April 25, 2013
15 Does night work increase the risk of breast cancer? A systematic review and meta-analysis of epidemiological studies Cancer Epidemiology, April 22, 2013 Review Article
16 Substantial breast cancer risk reduction and potential survival benefit after bilateral mastectomy when compared with surveillance in healthy BRCA1 and BRCA2 mutation carriers: a prospective analysis Annals of Oncology, April 16, 2013
17 Consensus on the regional lymph nodes irradiation in breast cancer Clinical and Translational Oncology, March 28, 2013
18 Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study The Lancet Oncology, April 19, 2013
19 Sedentary behavior, physical activity, and likelihood of breast cancer among black and white women: a report from the Southern Community Cohort Study Cancer Prevention Research, April 18, 2013
20 Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis The Lancet Oncology, March 29, 2013 Review Article
Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more
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