Oncology - Bone/Cartilage News & Articles

Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.

On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (1) Full Text Articles (52) Focus on Renal

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

461 The Role of MAPK Pathway in Bone and Soft Tissue Tumors Anticancer Research, March 28, 2011

462 Treatment outcome and prognostic factors in renal cell cancer patients with bone metastasis Clinical and Experimental Metastasis, March 25, 2011

463 Tumor-infiltrating macrophages are associated with metastasis suppression in high-grade osteosarcoma: a rationale for treatment with macrophage-activating agents Full Text Clinical Cancer Research, March 24, 2011

464 Steps in prostate cancer progression that lead to bone metastasis International Journal of Cancer, March 22, 2011

465 Metastatic osteosarcoma presenting as a singlepulmonary microembolus Journal of Pediatric Surgery, March 22, 2011

466 Dual-fibular Reconstruction of a Massive Tibial Defect After Ewings Sarcoma Resection in a Pediatric Patient With a Vascular Variation Journal of Pediatric Orthopaedics , March 22, 2011

467 High-Speed Burring with and without the Use of Surgical Adjuvants in the Intralesional Management of Giant Cell Tumor of Bone: A Systematic Review and Meta-Analysis Sarcoma, March 21, 2011 Evidence Based Medicine

468 Musculoskeletal Adverse Events Associated with Adjuvant Aromatase Inhibitors Journal of Oncology, March 21, 2011

469 Malignant Progression in Two Children with Multiple Osteochondromas Sarcoma, March 21, 2011

470 Laryngeal Chondrosarcoma: An Exceptional Localisation of a Not Unfrequent Bone Tumor Sarcoma, March 21, 2011

471 Extraosseous Osteosarcoma of the Esophagus: A Case Report Sarcoma, March 21, 2011

472 Imaging of Skeletal Metastases in Myxoid Liposarcoma Sarcoma, March 21, 2011

473 Use of a Distal Radius Endoprosthesis Following Resection of a Bone Tumour: A Case Report Sarcoma, March 21, 2011

474 Granular Cell Tumours: A Rare Entity in the Musculoskeletal System Sarcoma, March 21, 2011

475 Vascularized Fibula Grafts for Reconstruction of Bone Defects after Resection of Bone Sarcomas Sarcoma, March 21, 2011

476 Sclerosing Epithelioid Fibrosarcoma of the Bone: A Case Report of High Resistance to Chemotherapy and a Survey of the Literature Sarcoma, March 21, 2011

477 FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas Sarcoma, March 18, 2011

478 Computer-Assisted Resection and Reconstruction of Pelvic Tumor Sarcoma Sarcoma, March 18, 2011

479 Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy Cancer Science, March 17, 2011

480 UK Guidelines for the Management of Bone Sarcomas Sarcoma, March 16, 2011 Clinical Guideline

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Clinical Pearls in Oncology

The ZORO study demonstrated that the addition of goserelin to neoadjuvant chemotherapy for early breast cancer in premenopausal women resulted in no change in post-chemotherapy rates of amenorrhea
A little over 50% of tumors in women with ER-positive, node-negative breast cancers will have a RS <18, and current data suggests that these women are UNLIKELY to receive a benefit from adjuvant chemotherapy
In patients with completely resected ER-positive DCIS when the surgical specimen also has LCIS, consider breast MRI screening in addition to mammography due to the lower sensitivity of mammograms for lobular disease

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.

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HCC risk increased in patients with AIDS

As reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.

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RAB25 is a prognostic marker for ovarian cancer

As reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.

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Most Popular Oncology Articles

Last month's top read Top Articles of 2012

1 18F-FDG PET SUVmax as an indicator of histopathologic response after neoadjuvant chemotherapy in extremity osteosarcoma European Journal of Nuclear Medicine & Molecular Imaging, April 11, 2013

2 Preoperative and Therapeutic Embolization of Extremities of Bone and Soft Tissue Tumors Angiology, April 11, 2013

3 Pulmonary metastasectomy for osteogenic and soft tissue sarcoma: who really benefits from surgical treatment? European Journal of Cardio-Thoracic Surgery, April 5, 2013 Review Article

4 Incidence and relative survival of chordomas Cancer, April 4, 2013 Review Article

5 Osteosarcoma of the mobile spine Annals of Oncology, April 26, 2013

6 Risk of cancer following primary total hip replacement or primary resurfacing arthroplasty of the hip: a retrospective cohort study in Scotland British Journal of Cancer, April 5, 2013

7 Biological Reconstruction Following the Resection of Malignant Bone Tumors of the Pelvis Sarcoma, April 17, 2013

8 Do Malignant Bone Tumors of the Foot Have a Different Biological Behavior than Sarcomas at Other Skeletal Sites Sarcoma, April 1, 2013

9 The Correlation Between Dose of Folinic Acid and Neurotoxicity in Children and Adolescents Treated for Osteosarcoma With High-dose Methotrexate (HDMTX): A Neuropsychological and Psychosocial Study Journal of Pediatric Hematology/Oncology, April 29, 2013

10 MicroRNA-199b-5p is involved in the Notch signaling pathway in osteosarcoma Human Pathology, April 11, 2013

11 Repiphysis prosthesis for limb preservation in pediatric patients with bone cancer: a literature review Orthopaedic Nursing, April 8, 2013 Review Article

12 Soft Tissue Chordomas: A Clinicopathologic Analysis of 11 Cases American Journal of Surgical Pathology , April 26, 2013

13 Retrospective analysis of antitumor effects of zoledronic acid in breast cancer patients with bone-only metastases Cancer, April 16, 2012 Free full text

14 Giant Cell Tumor of Bone: Review, Mimics, and New Developments in Treatment RadioGraphics, January 21, 2013 Review Article

15 Osseous Myxochondroid Sarcoma: A Detailed Study of 5 Cases of Extraskeletal Myxoid Chondrosarcoma of the Bone American Journal of Surgical Pathology , April 29, 2013

16 Satb2 is a novel marker of osteoblastic differentiation In bone and soft tissue tumors Histopathology, April 4, 2013

17 A systematic review of vascular endothelial growth factor expression as a biomarker of prognosis in patients with osteosarcoma Tumor Biology, April 18, 2013 Review Article

18 A Disintegrin And Metalloproteinase 12 produced by tumour cells accelerates osteosarcoma tumour progression and associated osteolysis European Journal of Cancer, April 29, 2013

19 The Combination of Sorafenib and Everolimus Abrogates mTORC1 and mTORC2 Upregulation in Osteosarcoma Preclinical Models Clinical Cancer Research, April 12, 2013

20 Evaluation of Quercetin as a Potential Drug in Osteosarcoma Treatment Anticancer Research, April 11, 2013

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more

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Oncology - Bone/Cartilage News & Articles

Articles

Clinical Pearls in Oncology

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

HCC risk increased in patients with AIDS

RAB25 is a prognostic marker for ovarian cancer

Most Popular Oncology Articles

Other Topics in Oncology