Oncology - Basic Science/Genetics News & Articles

Looking for the latest in oncology clinical literature? You've found the right page. MDLinx Oncology medical editors comb through the top peer-reviewed clinical journals for the articles they think will make a difference to you and your practice. You'll find them organized here by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants and the whole cancer care team can stay current on the literature as it is published.

On this page, you'll also find MDLinx exclusive content, including monthly highlights from our physician editor, D. Scott Cunningham, MD, PhD. We feature clinical pearls as well, from The Smartest Oncologist to oncology topics in The Smartest Pediatrician daily quiz challenges.

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Articles

Latest (10) Full Text Articles (1557) Focus on Liver

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

981 Methylation of the hTERT promoter: a novel cancer biomarker for leptomeningeal metastasis detection in cerebrospinal fluids Clinical Cancer Research, March 5, 2013

982 CD44 and OTP are strong prognostic markers for pulmonary carcinoids Clinical Cancer Research, March 5, 2013

983 MicroRNA profiling can classify acute leukemias of ambiguous lineage as either acute myeloid leukemia or acute lymphoid leukemia Clinical Cancer Research, March 5, 2013 Clinical Article

984 Clinical correlates of promoter hypermethylation of four target genes in head and neck cancer: A Cooperative Group Correlative Study Clinical Cancer Research, March 5, 2013

985 Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer Cancer Cell, March 5, 2013 Clinical Article

986 Role of Brutons tyrosine kinase (BTK) in myeloma cell migration and induction of bone disease American Journal of Hematology, March 5, 2013 Clinical Article

987 A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non-Small Cell Lung Cancer Patients Clinical Cancer Research, March 5, 2013 Clinical Article

988 Functional Analysis of Genes in Regions Commonly Amplified in High-Grade Serous and Endometrioid Ovarian Cancer Clinical Cancer Research, March 5, 2013 Clinical Article

989 Recurrent loss of heterozygosity in 1p36 associated with TNFRSF14 mutations in IRF4 translocation negative pediatric follicular lymphomas Full Text Haematologica, March 5, 2013 Clinical Article

990 Low Expression of CyclinH and Cyclin-Dependent Kinase 7 Can Decrease the Proliferation of Human Esophageal Squamous Cell Carcinoma Digestive Diseases and Sciences, March 5, 2013 Clinical Article

991 A new cell culture-based assay quantifies VKORC1 function and reveals warfarin resistance phenotypes not shown by the DTT-driven VKOR assay Journal of Thrombosis and Haemostasis, March 5, 2013 Clinical Article

992 Myocyte enhancer factor 2C in hematopoiesis and leukemia Oncogene, March 5, 2013 Review Article Clinical Article

993 ATM kinase activity modulates ITCH E3-ubiquitin ligase activity Oncogene, March 5, 2013 Clinical Article

994 Long interspersed nuclear element ORF-1 protein promotes proliferation and resistance to chemotherapy in hepatocellular carcinoma Full Text World Journal of Gastroenterology, March 5, 2013 Clinical Article

995 Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations Molecular Cancer Research, March 5, 2013 Clinical Article

996 Glutathione S-transferase P1 Ile105Val polymorphism contributes to increased risk of gastric cancer in East Asians Tumor Biology, March 5, 2013 Evidence Based Medicine Clinical Article

997 KRAS allel-specific activity of sunitinib in an isogenic disease model of colorectal cancer Journal of Cancer Research & Clinical Oncology, March 5, 2013 Clinical Article

998 Pentoxifylline and the proteasome inhibitor MG132 induce apoptosis in human leukemia U937 cells through a decrease in the expression of Bcl-2 and Bcl-XL and phosphorylation of p65 Full Text Journal of Biomedical Science, March 5, 2013

999 Concurrent rearrangements of BCL2, BCL3, and BCL11A genes in atypical chronic lymphocytic leukemia Hematology, March 5, 2013

1000 The significance of MUM1/IRF4 protein expression and IRF4 translocation of CD30(+) cutaneous T-cell lymphoproliferative disorders: A study of 53 cases Leukemia Research, March 5, 2013 Clinical Article

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Clinical Pearls in Oncology

The ZORO study demonstrated that the addition of goserelin to neoadjuvant chemotherapy for early breast cancer in premenopausal women resulted in no change in post-chemotherapy rates of amenorrhea
A little over 50% of tumors in women with ER-positive, node-negative breast cancers will have a RS <18, and current data suggests that these women are UNLIKELY to receive a benefit from adjuvant chemotherapy
In patients with completely resected ER-positive DCIS when the surgical specimen also has LCIS, consider breast MRI screening in addition to mammography due to the lower sensitivity of mammograms for lobular disease

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

As reported in the Journal of Pathology, the expression of vascular endothelial growth factor receptor (VEGFR)-1 is elevated in invasive hepatocellular cancer (HCC) specimens. In a study based on 135 HCC specimens, elevated VEGFR-1 was also associated with worse recurrence-free and overall survival.

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HCC risk increased in patients with AIDS

As reported in Cancer, researchers from the NCI have reported that patients with AIDS have a 4-fold increased risk of HCC compared to the general population. The study findings were based on 615,150 patients with AIDS between 1980 and 2009. The risk for HCC in patients with AIDS was essentially the same during the monotherapy/dual therapy and highly active anti-retroviral therapy eras.

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RAB25 is a prognostic marker for ovarian cancer

As reported in the International Journal of Cancer Research and Treatment, the pre-operative level of RAB25 is a predictor of disease-free survival (HR=18.2) and overall survival (HR=33.6) in patients with ovarian cancer. The study involved 36 and 16 women with ovarian cancer and benign tumors, respectively. The pre-operative cell-free DNA of genes (B2M, RAB25, CLDN4, and ABCF2) were measured and RAB25 was shown to be an independent prognostic factor.

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Most Popular Oncology Articles

Last month's top read Top Articles of 2012

1 Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013 Mayo Clinic Proceedings, April 2, 2013 Clinical Guideline

2 Intrinsic Resistance to JAK2 Inhibition in Myelofibrosis Clinical Cancer Research, April 1, 2013

3 Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer New England Journal of Medicine, April 2, 2013

4 Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions Cochrane Reviews, April 1, 2013 Review Article

5 Leukaemia update. Part 1: diagnosis and management British Medical Journal, April 9, 2013 Review Article

6 Prognostic significance of the aggregative perivascular growth pattern of tumor cells in primary central nervous system diffuse large B-cell lymphoma Neuro-Oncology, March 26, 2013

7 P21-activated kinase 1 (pak1) as a therapeutic target in braf wild-type melanoma Journal of the National Cancer Institute, April 1, 2013

8 A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: implications for prognosis Annals of Oncology, April 1, 2013

9 Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013 Mayo Clinic Proceedings, April 9, 2013 Free full text Clinical Guideline

10 Cancer Immunotherapy: Present Status, Future Perspective, and a New Paradigm of Peptide Immunotherapeutics Discovery Medicine, April 1, 2013 Free full text Review Article

11 Aberrant BAF57 Signaling Facilitates Pro-metastatic Phenotypes Clinical Cancer Research, April 1, 2013

12 Serum levels of IL-6 and IL-1beta can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer British Journal of Cancer, April 24, 2013

13 CD133 expression is not an independent prognostic factor in stage II and III colorectal cancer but may predict the better outcome in patients with adjuvant therapy BMC Cancer, April 3, 2013 Free full text

14 Increased levels of urinary PGE-M, a biomarker of inflammation, occur in association with obesity, aging and lung metastases in patients with breast cancer Cancer Prevention Research, April 3, 2013

15 MYD88 L265P is a marker highly characteristic of, but not restricted to, Waldenström’s macroglobulinemia Leukemia, April 1, 2013

16 Vimentin expression predicts the occurrence of metastases in non small cell lung carcinomas Lung Cancer, April 12, 2013

17 Tumor-suppressive microRNA-145 targets catenin δ-1 to regulate Wnt/β-catenin signaling in human colon cancer cells Cancer Letters, April 2, 2013

18 Association of interleukin-10, tumor necrosis factor-alpha and transforming growth factor-beta gene polymorphisms with the outcome of diffuse large B-cell lymphomas International Journal of Clinical Oncology, March 29, 2013

19 Amiodarone and the risk of cancer Cancer, April 9, 2013

20 Expression of CD133 in acute leukemia Medical Oncology, April 2, 2013

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncology more

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Oncology - Basic Science/Genetics News & Articles

Articles

Clinical Pearls in Oncology

Highlights in Oncology

VEGFR-1 is a prognostic marker for HCC

HCC risk increased in patients with AIDS

RAB25 is a prognostic marker for ovarian cancer

Most Popular Oncology Articles

Other Topics in Oncology