The Latest Journal Articles in Oncology

1Effect of enzalutamide on health-related quality of life, pain, and skeletal-related events in asymptomatic and minimally symptomatic, chemotherapy-naive patients with metastatic castration-resistant prostate cancer (PREVAIL): results from a randomised, phase 3 trialThe Lancet Oncology, April 17, 2015  Clinical Article
2Phase I/II Study of HSP90 Inhibitor AUY922 and erlotinib for EGFR-mutant lung cancer with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitorsJournal of Clinical Oncology, April 17, 2015  Clinical Article
3Early tumor shrinkage and depth of response predict long-term outcome in metastatic colorectal cancer patients treated with first-line chemotherapy plus bevacizumab: results from phase III TRIBE trial by the Gruppo Oncologico del Nord OvestAnnals of Oncology, April 17, 2015  Clinical Article
4Life expectancy of colon, breast, and testicular cancer patients: an analysis of US-SEER population-based dataAnnals of Oncology, April 17, 2015  Clinical Article
5Plasma carotenoids and risk of breast cancer over 20 y of follow-upAmerican Journal of Clinical Nutrition, April 17, 2015  Clinical Article
6PIK3CA pathway mutations predictive of poor response following standard radiochemotherapy ± cetuximab in cervical cancer patientsClinical Cancer Research, April 17, 2015  Clinical Article
7Guidelines for time-to-event end point definitions in breast cancer trials: results of the DATECAN initiativeAnnals of Oncology, April 17, 2015
8Integrative molecular profiling of routine clinical prostate cancer specimensAnnals of Oncology, April 17, 2015  Clinical Article
9Mammographic density in relation to tumor biomarkers, molecular subtypes, and mode of detection in breast cancerCancer Causes and Control, April 17, 2015  Clinical Article
10The National Breast and Cervical Cancer Early Detection Program: 25 Years of public health service to low-income womenCancer Causes and Control, April 17, 2015  Review Article
1Scientists trace genomic evolution of high-risk leukemiaSt. Jude Children's Research Hospital News, April 17, 2015
2Measuring treatment response proves to be a powerful tool for guiding leukemia treatmentSt. Jude Children's Research Hospital News, April 17, 2015
3Cancer drug target also essential for blood cell recoveryThe Walter and Eliza Hall Institute of Medical Research News, April 17, 2015
4To stop cancer: Block its messagesWeizmann Institute of Science News, April 17, 2015
5NHMRC funds better targeted cancer imaging and radiotherapyThe University of Sydney News, April 17, 2015
6Gene variant linked to smoking longer, getting lung cancer soonerWashington University School of Medicine in St. Louis News, April 17, 2015
7Tumor-only genetic sequencing may misguide cancer treatment in nearly half of all patients, study showsJohns Hopkins Medicine, April 17, 2015
8Functionality of drug resistance in melanoma decodedMedical University of Vienna, April 17, 2015
9Early use of palliative care in cancer improves patients lives, outcomes for caregiversNorris Cotton Cancer Center News, April 17, 2015
10Ovarian cancer: Genetic testing should be accessible to all women with the diseaseMcGill University Health Centre News, April 17, 2015

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YKL-40 predicts poor prognosis for bladder cancer

As reported in Urologic Oncology, the gene expression and serum level of YKL-40 are higher in patients with bladder cancer than healthy controls. Serum YKL-40 levels predict poor prognosis in patients with muscle-invasive bladder cancer (HR=1.75).

Cisplatin monotherapy effective in pediatric high-risk hepatoblastoma

As reported in the Journal of Pediatric Hematology/Oncology, treatment of children with high-risk hepatoblastoma (n=14) with cisplatin monotherapy was as effective as cisplatin + doxorubicin combination therapy, but with less toxicity. The complete resection rate was 78.6%, the event-free survival rate was 81.8%, and the OS rate was 100%.

Loss of PTEN expression portends poor prognosis in IPMNs of the pancreas

As reported in Clinical Cancer Research, loss of PTEN in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas (n=36) is associated with invasiveness and poor survival.

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Clinical Pearl from Smartest DocCumulative adulthood UV exposure is associated with an increased risk of squamous cell and basal cell carcinoma.

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