The latest Cancer and Oncology news articles published daily by MDLinx physician editors who comb through the top peer-reviewed clinical journals for the medical articles that will make a difference to you and your practice. Organized by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants can stay current on latest oncology topics, symptoms, treatments, risk factors in Cancer and Hematology.
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1 Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): Final overall survival analysis of a randomised, double-blind, placebo-controlled phase 3 study The Lancet Oncology, January 26, 2015 Clinical Article
2 A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: The GAMMA trial Annals of Oncology, January 26, 2015 Clinical Article
3 Tea and coffee and risk of endometrial cancer: cohort study and meta-analysis American Journal of Clinical Nutrition, January 26, 2015 Clinical Article
4 Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies Annals of Oncology, January 26, 2015 Clinical Article
5 Survival after squamous cell and basal cell carcinoma of the skin: A retrospective cohort analysis International Journal of Cancer, January 26, 2015 Clinical Article
6 Garlic and onions: Their cancer prevention properties Cancer Prevention Research, January 26, 2015 Review Article
7 Management of chemotherapy-induced neutropenia: measuring quality, cost, and value Journal of the National Comprehensive Cancer Network, January 26, 2015 Clinical Article
8 A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study Neuro-Oncology, January 26, 2015 Clinical Article
9 The benefit of microsatellite instability is attenuated by chemotherapy in stage II and stage III gastric cancer: Results from a large cohort with subgroup analyses International Journal of Cancer, January 26, 2015 Clinical Article
10 Multicenter assessment of neoadjuvant chemotherapy for muscle-invasive bladder cancer Full Text European Urology, January 26, 2015 Clinical Article
11 Efficacy and cost-effectiveness of screening colonoscopy according to the adenoma detection rate United European Gastroenterology Journal, January 26, 2015 Clinical Article
12 Acquisition of relative interstrand crosslinker resistance and PARP inhibitor sensitivity in Fanconi anemia head and neck cancers Clinical Cancer Research, January 26, 2015 Clinical Article
13 The efficacy of the Wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood-brain barrier in glioblastoma Clinical Cancer Research, January 26, 2015 Clinical Article
14 Molecular pathways: The PERKs and pitfalls of targeting the unfolded protein response in cancer Clinical Cancer Research, January 26, 2015 Clinical Article
15 Ruxolitinib: a review of its use in patients with myelofibrosis Drugs, January 26, 2015 Review Article
16 Long-term persistence of oral human papillomavirus type 16: the HPV1 infection in men (HIM) study Cancer Prevention Research, January 26, 2015 Clinical Article
17 Which is the best advanced MR imaging protocol for predicting recurrent metastatic brain tumor following gamma-knife radiosurgery: focused on perfusion method Neuroradiology, January 26, 2015 Clinical Article
18 Comparison of tamsulosin plus serenoa repens with tamsulosin in the treatment of benign prostatic hyperplasia in Korean men: 1-year randomized open label study Urologia Internationalis, January 26, 2015 Clinical Article
19 Soy isoflavone intake and stomach cancer risk in Japan: From the Takayama study International Journal of Cancer, January 26, 2015 Clinical Article
20 Serum macrophage-derived chemokine/CCL22 levels are associated with glioma risk, CD4 T cell lymphopenia and survival time International Journal of Cancer, January 26, 2015 Clinical Article
As reported in the Journal of Pediatric Hematology/Oncology, treatment of children with high-risk hepatoblastoma (n=14) with cisplatin monotherapy was as effective as cisplatin + doxorubicin combination therapy, but with less toxicity. The complete resection rate was 78.6%, the event-free survival rate was 81.8%, and the OS rate was 100%.
As reported in JAMA—Otolaryngology-Head & Neck Surgery, patients with salivary gland tumors have an increased risk of second primary tumors and newly developed cancers. Specifically, the cumulative 2-, 5-, and 10-year rates for second primary cancers are 4.4%, 8.3%, and 12.4%, respectively. Similarly, the cumulative 2-, 5-, and 10-year rates for newly diagnosed cancers are 1.1%, 3.4%, and 10.5%, respectively.
As reported in Tumor Biology, VPAC1 expression is increased in poorly differentiated compared to well-differentiated colon cancer. VPAC1 expression is also increased in the blood vessels and macrophages adjacent to colon cancer tissues compared to healthy tissues. The overexpression of VPAC1 is related to EGFR overexpression.
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