The latest Cancer and Oncology news articles published daily by MDLinx physician editors who comb through the top peer-reviewed clinical journals for the medical articles that will make a difference to you and your practice. Organized by topic including breast, hematologic, thoracic, gastrointestinal and genitourinary cancers. In a matter of minutes, oncologists, oncology nurses, physician assistants can stay current on latest oncology topics, symptoms, treatments, risk factors in Cancer and Hematology.
1 Safety and tolerability of ixazomib, an oral proteasome inhibitor, in combination with lenalidomide and dexamethasone in patients with previously untreated multiple myeloma: An open-label phase 1/2 study The Lancet Oncology, November 21, 2014 Clinical Article
2 FOLFOX4 versus sequential dose-dense FOLFOX7 followed by FOLFIRI in patients with resectable metastatic colorectal cancer (MIROX): A pragmatic approach to chemotherapy timing with perioperative or postoperative chemotherapy from an open-label, randomised phase 3 trial Annals of Oncology, November 21, 2014 Clinical Article
3 Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer Journal of Clinical Oncology, November 21, 2014 Clinical Article
4 Zoledronic acid combined with adjuvant endocrine therapy of tamoxifen versus anastrozol plus ovarian function suppression in premenopausal early breast cancer: Final analysis of the Austrian Breast and Colorectal Cancer Study Group Trial 12 Annals of Oncology, November 21, 2014 Clinical Article
5 A multicenter phase II study of carboplatin and paclitaxel for advanced thymic carcinoma Annals of Oncology, November 21, 2014 Clinical Article
6 Nonlinear reduction in risk for colorectal cancer by oral contraceptive use: A meta-analysis of epidemiological studies Cancer Causes and Control, November 21, 2014 Evidence Based Medicine
7 Quality of cancer pain management: an update of a systematic review of undertreatment of patients with cancer Journal of Clinical Oncology, November 21, 2014 Review Article
8 A systematic review and meta-analysis of tobacco use and prostate cancer mortality and incidence in prospective cohort studies Full Text European Urology, November 21, 2014 Evidence Based Medicine
9 Prospective evaluation of magnetic resonance imaging guided in-bore prostate biopsy versus systematic transrectal ultrasound guided prostate biopsy in biopsy naïve men with elevated prostate specific antigen The Journal of Urology, November 21, 2014 Clinical Article
10 Omega-3 supplements for patients in chemotherapy and/or radiotherapy: A systematic review Clinical Nutrition, November 21, 2014 Clinical Article
11 Evidence for a time-dependent association between FOLR1 expression and survival from ovarian carcinoma: Implications for clinical testing. An Ovarian Tumour Tissue Analysis consortium study British Journal of Cancer, November 21, 2014 Clinical Article
12 Childhood cancer incidence patterns by race, sex and age for 2000 - 2006: A report from the South African national cancer registry International Journal of Cancer, November 21, 2014 Clinical Article
13 Enhanced immunosuppression by therapy-exposed glioblastoma multiforme tumor cells International Journal of Cancer, November 21, 2014 Clinical Article
14 Survival among patients with pancreatic cancer and long-standing or recent-onset diabetes mellitus Journal of Clinical Oncology, November 21, 2014 Clinical Article
15 Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters International Journal of Cancer, November 21, 2014 Clinical Article
16 Olfactory groove meningioma. Report of 99 cases surgically treated at the Catholic University School of Medicine, Rome World Neurosurgery, November 21, 2014 Review Article
17 A comparative study of single-port laparoscopic surgery versus robotic-assisted laparoscopic surgery for rectal cancer Surgical Innovation, November 21, 2014 Clinical Article
18 The nuclear bile acid receptor FXR controls the liver derived tumor suppressor Histidine-rich Glycoprotein International Journal of Cancer, November 21, 2014 Clinical Article
19 The prevalence and outcomes of frailty in older cancer patients: A systematic review Annals of Oncology, November 21, 2014 Review Article Clinical Article
20 No change in lymph node positivity rate despite increased lymph node yield and improved survival in colon cancer European Journal of Cancer, November 21, 2014 Clinical Article
As reported in the European Journal of Obstetrics and Gynecology & Reproductive Biology, levels of the adipokine, apelin, are decreased in women with PCOS (n=45) compared to healthy controls. Apelin levels are positively correlated with BMI, insulin levels, triglycerides levels, free testosterone levels, the Ferriman-Gallwey score, and the HOMA index. Apelin levels are negatively correlated with HDL levels.
As reported in The Lancet Oncology, circulating tumor cell (CTC) quantification in patients (20 studies; n = 1944) with metastatic breast cancer (mBC) predicts progression-free survival (PFS) and overall survival (OS), especially when coupled with clinicopathologic data. A CTC count ≥ 5/7.5 mL at baseline is associated with decreased PFS (HR = 1.92) and OS (HR = 2.78). An elevated CTC count 3-5 weeks and 6-8 weeks after treatment commences is also associated with decreased PFS (HR = 1.85 and 2.20) and OS (HR = 2.26 and 2.91).
As reported in the Journal of Pediatric Hematology/Oncology, treatment of children with high-risk hepatoblastoma (n=14) with cisplatin monotherapy was as effective as cisplatin + doxorubicin combination therapy, but with less toxicity. The complete resection rate was 78.6%, the event-free survival rate was 81.8%, and the OS rate was 100%.