Increased incidence of second primary cancers in patients with salivary gland tumors
As reported in JAMA—Otolaryngology-Head & Neck Surgery, patients with salivary gland tumors have an increased risk of second primary tumors and newly developed cancers. Specifically, the cumulative 2-, 5-, and 10-year rates for second primary cancers are 4.4%, 8.3%, and 12.4%, respectively. Similarly, the cumulative 2-, 5-, and 10-year rates for newly diagnosed cancers are 1.1%, 3.4%, and 10.5%, respectively.
YKL-40 predicts poor prognosis for bladder cancer
As reported in Urologic Oncology, the gene expression and serum level of YKL-40 are higher in patients with bladder cancer than healthy controls. Serum YKL-40 levels predict poor prognosis in patients with muscle-invasive bladder cancer (HR=1.75).
Loss of PTEN expression portends poor prognosis in IPMNs of the pancreas
As reported in Clinical Cancer Research, loss of PTEN in intraductal papillary mucinous neoplasms (IPMNs) of the pancreas (n=36) is associated with invasiveness and poor survival.