Accelerated intensity-modulated radiotherapy plus temozolomide in patients with glioblastoma: a phase I dose-escalation study (ISIDE-BT-1)
International Journal of Clinical Oncology, 08/21/2012
Clinical Article
Massaccesi M et al. – By using a simultaneous integrated boost (SIB) intensity–modulated radiotherapy (IMRT) technique, a radiation dose of 70Gy in 25 fractions (biological effective dose—BED—of 92.8Gy) can be delivered with concurrent and sequential standard dose temozolomide (TMZ), without unacceptable acute toxicity in patients with glioblastoma.



