Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition
Cancer Research, 08/17/2012
Casas–Selves M et al. – The findings therefore reveal a critical role for tankyrase and the canonical Wnt pathway in maintaining lung cancer cells during EGFR inhibition. Targeting the Wnt–tankyrase–β–catenin pathway together with EGFR inhibition may improve clinical outcome in patients with non–small cell lung cancer (NSCLC).