p53 codon 72 polymorphism and hepatocellular carcinoma: a meta-analysis
Hepatology International, 08/21/2012
Evidence Based Medicine
Jia S et al. – The meta–analysis suggests that p53 condon 72 Pro/Progenotypes are associated with increased risk of Hepatocellular carcinoma (HCC) in Caucasian.Methods
- Electronic search of PubMed was conducted to select studies.
- Studies containing available genotype frequencies of Arg72Pro were chosen, and pooled odds ratio (OR) with 95 % confidence interval (CI) was used to assess the association.
- Ten published studies, including 1,371 HCC cases and 2,517 controls were identified.
- The overall results suggested that the variant genotypes were associated with the HCC risk (Pro/Pro vs. Pro/Arg + Arg/Arg: OR 1.355, 95 % CI 1.041-1.764, p=0.024).
- In the stratified analysis, individuals with the Pro/Pro in the recessive model had increased risk of HCC (OR 1.927, 95 % CI 1.127-3.297, p=0.017) in Caucasian.
- A symmetric funnel plot, the Begg’s test, was suggestive of the lack of publication bias.
- There was no association between the p53 codon 72 polymorphism and HBV/HCV-positive HCC.