Oncogenic braf(v600e) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma
Clinical Cancer Research, 08/10/2012
Khalili JS et al. – This study reveals a novel mechanism of immune suppression sensitive to BRAF(V600E) inhibition, and suggests that clinical blockade of IL–1 may benefit patients with BRAF wild–type tumors and potentially synergize with immunotherapeutic interventions.



