Induced apoptosis in human prostate cancer cells by blocking of vascular endothelial growth factor by siRNA
Clinical and Translational Oncology, 08/01/2012
Deezagi A et al. – The findings indicate that siRNA are effective in eliciting the RNAi pathway in cancerous cells and that specific siRNA efficiently down–regulate VEGF expression. They could decrease Vascular endothelial growth factor (VEGF) production and induce apoptosis, which may also be linked to the inhibition of cancerous cell proliferation. Therefore, it can be concluded that siRNA–mediated suppression of VEGF represents a powerful tool against prostate cancer cell proliferation. VEGF down–regulation exerts a direct anti–apoptotic function in the DU–145 cell lines and promises the development of drugs for cancer therapy.