Effectiveness of oxaliplatin desensitization protocols
Clinical and Translational Oncology, 08/10/2012
Cortijo–Cascajares S et al. – This study confirms that oxaliplatin desensitization protocols are safe and effective and allow patients to continue with the treatment that initially caused an Hypersensitivity reaction (HSR).Methods
- A retrospective observational study was carried out between January 2006 and May 2011.
- The inclusion criteria were patients undergoing chemotherapy treatment with oxaliplatin who had developed an HSR to the drug and who were candidates for continuing the treatment using a desensitization protocol.
- The patients’ clinical records were reviewed and variables were gathered relating to the patient, the treatment, the HSR, and the desensitization protocol administered.
- The data were analysed using version 18.0 of the statistics program SPSS.
- A total of 53 desensitization protocols were administered to 21 patients.
- In 89 % of these cases, no new reactions occurred while the drug was being administered.
- New reactions of mild severity only occurred in 11 % of cases, and none of these reactions were severe enough for treatment to be stopped.
- All patients were able to complete the desensitization protocol.