Surgery of primary tumors in stage IV breast cancer: an updated meta-analysis of published studies with meta-regression
Medical Oncology, 08/01/2012
Evidence Based Medicine
Petrelli F et al. – According to meta–regression, the survival benefit was independent of age, extent, site of the metastatic disease, and HER2 status, but was directly proportional to the rate of patients exposed to systemic therapies and radiotherapy and inversely correlated with the ER+ status of the population included. Surgery of the primary tumor in stage IV breast cancer seems to offer a survival benefit in metastatic patients, in particular when it is offered in a multimodality treatment program.