Touch Imprint Cytology and Frozen-section Analysis for Intraoperative Evaluation of Sentinel Nodes in Early Breast Cancer
Anticancer Research, 07/27/2012
Lumachi F et al. – The preliminary data confirm that imprint cytology (IC) is a simple and rapid technique with good sensitivity, suggesting that the combination of frozen–section (FS) and IC may be useful in all patients requiring intraoperative Sentinel lymph node biopsy (SLNB) evaluation.Methods
- A series of 126 consecutive women (median age 52, range 34-71years) with T1 (≤20mm) BC, were prospectively enrolled in the study.
- A total of 221 axillary nodes were processed for both IC and FS intraoperative evaluation.
- Final pathology revealed 74 out of 221 (33.5%) nodes with metastasis, out of which 51 (68.9%) had macrometastases.
- Overall, 31 out of 126 (24.6%) patients were staged as having pN1mi or pN1a.
- The sensitivity, specificity, and accuracy in detecting metastases were 75.7%, 100% and 91.9% for FS, 70.3%, 98.6% and 89.1% for IC, and 89.2%, 100% and 96.0% for IC+FS together, respectively.
- The sensitivity of FS and IC did not differ significantly (p=0.46), while the combination of FS+IC showed a higher sensitivity (p=0.03), and similar accuracy.