Increased Gene Expression of the ABCC5 Transporter without Distinct Changes in the Expression of PDE5 in Human Cervical Cancer Cells during Growth
Anticancer Research, 07/27/2012
Eggen T et al. – The malignant cells exhibited moderate ABCC5 expression with a distinct increase during exponential growth, whereas PDE5 expression remained virtually unchanged. Dysregulation of the 3',5'–cyclic monophosphate (cGMP) biokinetics in growing malignant cells may account for the elevation of extracellular cGMP observed in patients with carcinoma of the uterine cervix.