Long-term outcome of continuous 5-fluorouracil/cisplatin-based chemotherapy followed by chemoradiation in patients with resected gastric cancer
Medical Oncology, 07/16/2012
Sonnenblick A et al. – long-term follow-up demonstrates that postoperative chemoradiation with combination of bolus 5-fluorouracil, continuous 5-fluorouracil, and cisplatin is a feasible approach.
Methods- The study population consisted of 36 advanced gastric cancer patients.
- Patients were treated with six cycles of continuous 5-fluorouracil (600 mg/m2) for 24 h, push 5-fluorouracil (400 mg/m2), and leucoverin (LCV) (200 mg/m2) on day 1–2 every 2 weeks, cisplatin (60 mg/m2) on day 1 every 4 weeks followed by combined modality therapy using 45 Gy at 1.8 Gy per day concomitant with weekly bolus 5-fluorouracil (600 mg/m2) and LCV (50 mg).
- After median follow-up of 48.9 months, the median disease-free survival was 45 months and the overall survival was 66.4 months.
- Sixteen patients (44 %) were alive and disease-free.
- There was no significant correlation between ERCC1 expression and TS expression pattern and time to relapse (P = 0.302 and P = 0.707, respectively).
