Ecstacy-induced delayed rhabdomyolysis and neuroleptic malignant syndrome in a patient with a novel variant in the ryanodine receptor type 1 gene
Russell T et al. – The authors present the case of a 20–year–old woman who developed rhabdomyolysis, disseminated intravascular coagulopathy and multi–organ failure induced by ecstasy. Following initial improvement, she developed delayed rhabdomyolysis then haloperidol–induced neuroleptic malignant syndrome, which was treated with a total of 50 mg.kg–1 dantrolene. Subsequent genetic testing revealed a novel potentially pathogenic variant in the ryanodine receptor type 1 gene. However, caffeine–halothane contracture testing of the patient's mother who carried the same gene variant was negative for malignant hyperthermia.