Patterns of adjuvant hormonal therapy use in the northern California breast cancer family registry
Journal of Women's Health, 06/27/2012
Livaudais JC et al. – Racial/ethnic differences in adjuvant hormonal therapy use were limited to earlier diagnosis years (phase I) and were attenuated over time. Findings should be confirmed in other populations but indicate that in this population, treatment disparities between African American and Asian American women narrowed over time as adjuvant hormonal treatments became more commonly prescribed.Methods
- Odds ratios (OR) comparing self–reported ever–use by race/ethnicity (African American, Hispanic, non–Hispanic white vs. Asian American) were estimated using multivariable adjusted logistic regression.
- Analyses were stratified by recruitment phase (phase I, diagnosed January 1995–September 1998, phase II, diagnosed October 1998–April 2003) and genetic susceptibility, as cases with increased genetic susceptibility were oversampled.
- Among 1385 women (731 phase I, 654 phase II), no significant racial/ethnic differences in use were observed among phase I or phase II cases.
- However, among phase I cases with no susceptibility indicators, African American and non–Hispanic white women were less likely than Asian American women to use hormonal therapy (OR 0.20, 95% confidence interval [CI]0.06–0.60; OR 0.40, CI 0.17–0.94, respectively).
- No racial/ethnic differences in use were observed among women with 1+ susceptibility indicators from either recruitment phase.