Prognostic importance of the inflammation-based Glasgow prognostic score in patients with gastric cancer
British Journal of Cancer, 06/21/2012
Jiang X et al. – The preoperative mGPS is a simple and useful prognostic factor for postoperative survival in patients with gastric cancer.Methods
- The mGPS (0=C-reactive protein (CRP)10 mg/l, 1=CRP>10 mg/l and 2=CRP>10 mg/l and albumin<35 g/l) was calculated on the basis of preoperative data for 1710 patients with gastric cancer who underwent surgery between January 2000 and December 2007.
- Patients were given an mGPS of 0, 1 or 2. The prognostic significance was analysed by univariate and multivariate analyses.
- Increased mGPS was associated with male patient, old age, low body mass index, increased white cell count and neutrophils, elevated carcinoembryonic antigen and CA19-9 and advanced tumour stage.
- Kaplan–Meier analysis and log-rank test revealed that a higher mGPS predicted a higher risk of postoperative mortality in both relative early-stage (stage I; P<0.001) and advanced-stage cancer (stage II, III and IV; P<0.001).
- Multivariate analysis demonstrated the mGPS to be a risk factor for postoperative mortality (odds ratio 1.845; 95% confidence interval 1.184–2.875; P=0.007).