Gamma-secretase inhibition promotes cell death, Noxa upregulation and sensitization to BH3 mimetic ABT-737 in human breast cancer cells Full Text
Breast Cancer Research, 06/26/2012
Seveno C et al. – The authors provide evidence that –secretase, and downstream Notch signalling, are relevant targets in breast cancer. GSIXII, used as single agent or in combination with clinically relevant BH3–mimetics, is a promising innovative pro–apoptotic strategy to treat mammary tumors.