Increased Expression of ABCB6 Enhances Protoporphyrin IX Accumulation and Photodynamic Effect in Human Glioma
Annals of Surgical Oncology, 06/22/2012
Zhao SG et al. – The findings indicate a crucial role of ABCB6 in ALA metabolism and accumulation of protoporphyrin IX (PpIX) in glioma. ABCB6 overexpression is a potential approach to enhance accumulation of PpIX for optimizing the subjective discrimination of vague fluorescence and improving the efficacy of ALA–based photodynamic therapy.