Phosphorylated and small ubiquitin-like modifier protein-deficient progesterone receptors drive proliferative gene signatures during breast cancer progression Full Text
Breast Cancer Research, 06/15/2012
Knutson TP et al. – The authors conclude that reversible Progesterone receptors (PR) SUMOylation/deSUMOylation profoundly alters target gene selection in breast cancer cells. Phosphorylation–induced PR deSUMOylation favors a permissive chromatin environment via recruitment of CBP and MLL2. Patients whose ER+/PR+ tumors are driven by hyperactive (i.e. derepressed) phospho–PRs may benefit from endocrine (antiestrogen) therapies that contain an antiprogestin.