Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors Full Text
BMC Cancer, 06/15/2012
Hsu C-L et al. – Low BMI, stage IV disease, anemia at diagnosis, and male gender were the negative prognostic factors for young patients with advanced NSCLC.Methods
- From January 2000 to December 2009, we enrolled patients aged [less than or equal to]45 years and diagnosed with stage IIIB or IV NSCLC.
- Their clinical data, including age, gender, performance status, histologic types, disease stages, laboratory data at diagnosis, treatment modalities, and survival were reviewed and analyzed.
- A Cox proportional hazard model was used to calculate the hazard ratio (HR) and its 95% confidence interval (CI).
- A total of 144 patients with advanced NSCLC were included.
- Female patients were more prevalent (n = 74, 51.4%).
- Adenocarcinoma was the most common histologic type (n = 119, 82.6%) in both genders (male, n = 54, 77.1%; female, n = 65, 87.8%).
- Epidermal growth factor receptor (EGFR) sequences were determined using tumor specimens from 58 patients, and 29 showed an EGFR mutation.
- No significant difference in median survival was found between patient groups with and without the EGFR mutation (798 vs. 708 days, p = 0.65).
- In multivariate analysis, male gender (HR, 1.70; 95% CI: 1.08-2.68), body mass index (BMI) less than 25 kg/m2(HR, 2.72; 95% CI: 1.39-5.30), stage IV disease (HR, 2.62; 95% CI: 1.50-4.57), and anemia (HR, 2.08; 95% CI: 1.15-3.77) were associated with a short survival time.