Failure patterns correlate with the tumor response after preoperative chemoradiotherapy for locally advanced rectal cancer
Journal of Surgical Oncology,

Lim SB et al. – More than one–third of patients with locally advanced rectal cancer showed good response to CRT, with improved local and systemic recurrence rates, especially low rates of pulmonary and systemic lymph node recurrence. Recurrence occurred earlier in the GR than the PR group, and oncologic outcomes after recurrence did not differ between the two groups.

  • Response to CRT was evaluated according to tumor regression grade (TRG), with 581 patients categorized into two groups, a good response (GR, TRG 3/4, n=224) and a poor response (PR, TRG 1/2, n=357) group.

  • At a mean follow–up of 61 months, the 5–year overall (88.2% vs. 71.3%, P<0.001) and disease–free (86.7% vs. 63.6%, P<0.001) survival rates were higher in the GR group.
  • In patients with recurrence, time to recurrence was shorter (13.5 months vs. 18.7 months, P=0.01), and the cumulative 2–year recurrence rates (92.9% vs. 73.4%, P=0.024) was higher in the GR group.
  • Rates of local (1.3% vs. 9.5% P<0.001) and systemic (11.6% vs. 27.2%, P<0.001) recurrence were significantly lower in the GR group, as were rates of pulmonary (3.6% vs. 15.1%, P<0.001) and systemic lymph node (1.3% vs. 5.9%, P=0.009) recurrences.
  • The 5–year overall survival rates after recurrence were similar (GR: 23.7% vs. PR: 16.0%, P=0.911).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Oncology

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Oncology Articles

1 The elevated preoperative platelet to lymphocyte ratio predicts decreased time to recurrence in colon cancer patients The American Journal of Surgery, July 25, 2014    Clinical Article

2 Continuous versus intermittent chemotherapy strategies in metastatic colorectal cancer: a systematic review and meta-analysis Annals of Oncology, July 29, 2014    Evidence Based Medicine    Review Article

3 Patterns of metachronous metastases after curative treatment of colorectal cancer Cancer Epidemiology, August 11, 2014    Clinical Article

4 The relationship between tumour stroma percentage, the tumour microenvironment and survival in patients with primary operable colorectal cancer Annals of Oncology, February 4, 2014    Clinical Article

5 Managing skin toxicities related to panitumumab Journal of the American Academy of Dermatology, August 11, 2014    Clinical Article

6 The role of biological therapy in metastatic colorectal cancer after first-line treatment: a meta-analysis of randomised trials British Journal of Cancer, August 6, 2014    Evidence Based Medicine    Clinical Article

7 FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial The Lancet Oncology, August 4, 2014    Clinical Article

8 Extended RAS mutations and anti-EGFR monoclonal antibody survival benefit in metastatic colorectal cancer: A meta-analysis of randomized controlled trials Annals of Oncology, August 26, 2014    Evidence Based Medicine

9 KRAS mutation profile differences between rectosigmoid localized adenocarcinomas and colon adenocarcinomas Full Text Journal of Gastrointestinal Oncology, August 13, 2014    Free full text    Clinical Article

10 Prognostic impact of primary tumor resection and lymph node dissection in stage IV colorectal cancer with unresectable metastasis: A propensity score analysis in a multicenter retrospective study Annals of Surgical Oncology, August 7, 2014    Clinical Article

11 Dose escalating study of cetuximab and 5-FU/ folinic acid (FA)/ oxaliplatin / irinotecan (FOLFOXIRI) in first line therapy of patients with metastatic colorectal cancer Full Text BMC Cancer, August 7, 2014    Free full text

12 Impact of acellular mucin pools on survival in patients with complete pathological response to neoadjuvant treatment in rectal cancer International Journal of Surgery, August 11, 2014    Clinical Article

13 Outcomes in the surgical treatment of low rectal cancer: does neoadjuvant treatment equalize results? ANZ Journal of Surgery, August 22, 2014

14 Yttrium-90 radioembolization of hepatic metastases from colorectal cancer Frontiers in Oncology, August 7, 2014    Review Article

15 Difference in the recurrence rate between right- and left-sided colon cancer: a 17-year experience at a single institution Surgery Today, August 25, 2014    Clinical Article

16 The human gut microbiome as a screening tool for colorectal cancer Cancer Prevention Research, August 12, 2014    Clinical Article

17 Primary sclerosing cholangitis as an independent risk factor for colorectal cancer in the context of inflammatory bowel disease: A review of the literature Full Text World Journal of Gastroenterology, July 28, 2014    Free full text    Review Article

18 Neuropathic symptoms, quality of life, and clinician perception of patient care in medical oncology outpatients with colorectal, breast, lung, and prostate cancer Journal of Cancer Survivorship, August 7, 2014    Clinical Article

19 Anti-EGFR MoAb treatment in colorectal cancer: limitations, controversies, and contradictories Cancer Chemotherapy and Pharmacology, June 17, 2014    Review Article

20 The role of adjuvant chemotherapy in stage II colorectal cancer patients International Journal of Colorectal Disease, July 15, 2014    Clinical Article

Indexed Journals in Oncology: Journal of Clinical Oncology, Cancer Research, Annals Oncologymore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More