Molecular investigation of lymph nodes in colon cancer patients using one-step nucleic acid amplification (OSNA)
Guller U et al. – One–step nucleic acid amplification (OSNA) appeared to be a powerful and promising molecular tool for the detection of lymph node metastases in patients with colon cancer. OSNA had similar performance in the detection of lymph node metastases compared with intensive histopathologic investigations and appeared to be superior to standard histology with hematoxylin and eosin (H&E). Most important, the authors concluded that OSNA may lead to a potential upstaging of >15% of patients with colon cancer.