Correlation between age and Chromogranin A determination in prostate diseases
Cancer Biomarkers, 06/12/2012
Mearini L et al. – Age, correlating with CgA values in overall population and in PC subgroup, emerged as a confounding factor in CgA determination. Serum CgA has not been demonstrated as a diagnostic marker of PC being only a marker of neuroendocrine differentiation. Cga values did not correlate with other clinical prognostic factors, except age, in untreated-naive PC.
Methods- Serum levels of CgA were determinated in 217 consecutive patients immediately before prostate biopsy:
- CgA differences between cases (prostate cancer PC) and control (benign prostatic hyperplasia BPH) were analyzed, and CgA performance in prediction of PC was compared with age and standard diagnostic tools.
- CgA values were also analyzed in patients affected by PC, and compared with age and standard prognostic parameters.
- At multivariate analysis, CgA approaches a statistically significant value as independent predictor of PC and positively correlates with age.
- In PC group, CgA positively correlates with age, while no correlations are found with PSA, Gleason score or stage of disease.
