Liver resection for complicated hepatocellular carcinoma: Challenges but opportunity for long-term survivals
Journal of Surgical Oncology, 05/31/2012
Huang JF et al. – Liver resection (LR) for cHCC can be a great challenge for liver surgeons. However, with comparable operative mortality rates and acceptable survival times, surgical resection should always be considered performing in patients with complicated HCC (cHCC), if clinically feasible.Methods
- Authors retrospectively reviewed 660 HCC patients who underwent LR between January 2001 and July 2005.
- The patients were grouped into cHCC and non–cHCC according to the defined criteria.
- The clinicopathological features were analyzed and compared between the two groups.
- Patients in the cHCC group required longer operative times and resulted in greater intraoperative blood loss and more severe surgical complications.
- The cHCC group had a higher incidence of HCC recurrence after LR, and the HCC recurrence had a tendency to be associated with extrahepatic metastasis.
- The 5–year RFS (P<0.0001) and OS (P<0.0001) of cHCC and non–cHCC patients were 18.5% and 28.9% versus 37.5% and 57.6%, respectively.