A prospective study of bisphosphonate use and risk of colorectal cancer
Journal of Clinical Oncology, 06/04/2012
Khalili H et al. – In a large prospective cohort, we did not observe an association between long-term use of bisphosphonates and risk of colorectal cancer.Methods
- We prospectively examined the relationship between bisphosphonate use and risk of colorectal cancer among 86,277 women enrolled onto the Nurses Health Study (NHS).
- Since 1998, participants have returned biennial questionnaires in which they were specifically queried about the regular use of bisphosphonates.
- We used Cox proportional hazards models to calculate hazard ratios (HRs) and 95% CIs for risk of colorectal cancer.
- Through 2008, we documented 801 cases of colorectal cancer over 814,406 person-years of follow-up.
- The age-adjusted HR for women who regularly used bisphosphonates was 0.92 (95% CI, 0.73 to 1.14) and was further attenuated after adjustment for other risk factors (multivariate HR, 1.04; 95% CI, 0.82 to 1.33).
- The risk was not influenced by duration of use (Ptrend = 0.79). Compared with nonusers, the multivariate-adjusted HRs of colorectal cancer were 1.24 (95% CI, 0.94 to 1.64) for women with 1 to 2 years of use, 1.16 (95% CI, 0.79 to 1.69) for 3 to 4 years of use, and 0.97 (95% CI, 0.60 to 1.56) for ? 5 years of use.
- There was no association between bisphosphonate use and colorectal cancer within strata of other risk factors.