Platelet-directed gene therapy overcomes inhibitory antibodies to factor viii
Journal of Thrombosis and Haemostasis, 05/31/2012
Chuah MK et al. – Some patients develop neutralizing antibodies (clinically referred to as “inhibitors”) to these exogenous clotting factors that renders further therapy ineffective. Consequently, patients with inhibitory antibodies suffer frequent bleeds, just like untreated patients.