ZEB1 promotes invasion and bone metastasis of small cell lung cancer in vitro and in vivo
Cancer Science, 06/13/2012
Liu Y et al. – The authors also found that SBC–3 cells underwent epithelial–mesenchymal transition (EMT), as indicated by decreased epithelial markers and increased mesenchymal markers expression. Taken together, these results indicated that ZEB1 promoted the invasive ability and bone metastasis of SCLC cells, and that this was partially mediated via the EMT pathway.