Acetylation of histone H3 prevents resistance development caused by chronic mTOR inhibition in renal cell carcinoma cells
Cancer Letters, 06/13/2012
Juengel E et al. – Combined drug application did not inactivate Akt but rather resulted in H3 acetylation remaining high while renal cell carcinoma (RCC) cell growth was still reduced. siRNA experiments revealed that histone H3 acetylation is responsible for preserving drug sensitivity in RCCs.